L.G. Hakobyan - Dr. Sc. (Biol.), Leading Research Scientist, Scientific and Production Center «Armbiotech-nology» - «Institute of Microbiology», NAS of RA (Yerevan, Armenia). E-mail: laurhakobyan@gmail.com P.A. Ghazaryan - Dr. Sc. (Biol.), Professor, Deputy Director on Science, Centre of Haematology n.a. prof. R. Yolyan, CJSC, Ministry of Health RA (Yerevan, Armenia). E-mail: ghazarpa@mail.ru M.A. Aleksandryan - Ph. D. (Med.), Head of Production Department, Centre of Haematology n.a. prof. R.Yolyan, CJSC, Ministry of Health RA (Yerevan, Armenia). E-mail: matevos.alexandryan@yandex.ru K.V. Harutyunyan - Post-graduate Student, Department of Microbiology & Plants and Microbes Biotechnology, Yerevan State University; Junior Research Scientist, Scientific and Production Center «Armbiotechnology»-«Institute of Microbiology», NAS of RA (Yerevan, Armenia). E-mail: k.v.harutyunyan@gmail.com A. Trchounian - Dr.Sc. (Biol.), Professor, Corresponding Member of NAS of RA, Head of Department of Mi-crobiology & Plans and Microbes Biotechnology, Yerevan State University, (Yerevan, Armenia). E-mail: Tr-chounian@ysu.am

The aim of this work is the study of probiotic lactic acid bacteria of strain «Narine» with high adhesive and antagonistic properties for usage in the treatment of acute childhood leucosis. The studies included children aged 7-12 years old who had been hospitalized in the hematology hospital. Antagonistic properties of bacteria were determined using diffusion method in agar and by serial dilutions. To identify the adhesion properties in bacterial cells the hemagglutination reaction is used with red blood cells of birds, animals and humans. From the patients with acute leucosis were isolated and identi-fied S. aureus, S. epidermidis, E. coli, which differed from the phage types. It was determined that the pathogenic microorganisms are isolated at a stage of acute leucosis, while saprophyte microorganisms - at a stage of remission. The quantity of Escherichia (E.coli) was decreasing in blood and in feces during enteral supplementation of L. acidophilus strain Er 317/402 «Narine», while on the 10-12th days after acidophilotherapy hemolytic Escherichia were not detected. The strain is recommended for treatment of childhood leucosis.

 

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