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Journal Technologies of Living Systems №4 for 2015 г.
Article in number:
The static magnetic field influence on proliferation of cancer cells
Keywords: magnetic field cancer (neoplastic ) cells magneto-biology
Authors:
A.V. Gulyaev - Dr.Sc. (Med.), Professor, Leader Abdominal Oncology Surgical Department, FGBU «Research Institue for Oncology named after N.N. Petrov», Saint-Petersburg, Russia B.M. Kondratenko - Dr.Sc. (Eng.), Professor, Leading Research Scientist, Research Institute for Shipbuilding and Arma-ment, Russian Navy MERC «Navy Academy». E-mail: mkondratenko@bk.ru
Abstract:
Paper is dedicated to a study of still not completely understood problem of static magnetic field influencing the growth of neoplastic population. The study\' goal was to determine quantitative characteristics of relationships between the neoplastic population growth and induction quantity of magnetic field and its exposure time, as well as to assess how spatial configu-ration of magnetic field influences the process of neoplastic cells growth. Investigation techniques involved suspended cell cultivation in a compositionally standard medium in Petri dishes. These dishes rested upon permanent magnets were placed into a thermostat for 24, 48, 72, 96 hours. Moreover, the dishes could be placed in magnetic field generated with three mutually orthogonal permanent magnets. As a result of the study, the following has been found. Static magnetic field with induction rang of 20-180 mTl accelerates cancer cells growth in cell lines K 562. It was noticed, that the maximum growth rate of neoplastic population was observed when the latter was influenced by the three mutually orthogonal magnetic fields. Magnetic field influence quantity depends on induction values and on exposure time. The maximum influence on the cell population growth is exerted by the field with induction of 30-80 mTl. The presence of magnetic field induction extremum at 46±1 mTl was found, whereby the rate of cell growth, for example, by 50% exceeds that in the field with induction of 170 mTl. The suggestion has been made that the static magnetic field influence could tell on biochemical reactions of energy carrier synthesis which reactions take place in cell molecular structure and manifest themselves by spin-spin interactions of chemical elements involved in reactions.
Pages: 46-50
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