A.A. Prosvirin - Assistant, Department of Traumatology and Orthopedics, Moscow State Medical and Dental University n.a. A.I. Evdokimov. E-mail: homik24@mail.ru E.D. Sklyanchuk. - Dr.Sc. (Med), Professor (19592015) V.V. Guriev - Dr.Sc. (Med), Professor, Head of the Center of Traumatology and Orthopedics of The Railway Clinical Hospital named N.A. Semashko at Lublin Station of «Russian Railways» Moscow. E-mail: drguriev@mail.ru V.N. Gorshenev - Ph.D. (Phis.-Math.), Senior Research Scientist, The Institute of Biochemical Physics named N.M. Emanuel of the RAS, Moscow. E-mail: gor@sky.chph.ras.ru A.T. Teleshev - Dr.Sc. (Chim.), Professor, Chair of Physical and Analytical Chemistry of the Moscow Pedagogical State University. E-mail: telechevat@rambler.ru V.S. Akatov - Dr.Sc. (Phis.-Math.), Professor, Head of Laboratory of Tissue Engineering of The Institute of Teoretical and Experimental Biophysics of the RAS, Moscow region, Pushchino. E-mail: v-akatoff@rambler.ru M.V. Parshikov - Dr.Sc. (Med.), Professor, Moscow State Medical and Dental University n.a. A.I. Evdokimov

The work investigated the osteogenic properties developed collagen-apatite material into the skull defect model in rats. Studies using cell culture methods, histology, confocal microscopy showed that the material is biocompatible, does not possess inflammatory local irritating action does not impede the osteogenesis. A clinical case of the treatment of osteomyelitis of the developed technique with the liquidation of purulent-necrotic process in the bone and absence of recurrence of the disease within 3 years.Supplied osteomyelitis model in rats with the development of the fistula forms. The experimental group received the closure of the fistulous, with the restoration of bone tissue. The results indicate the prospects of the developed material to repair damaged bone. The proposed method makes it possible to eliminate the process of osteomyelitis, save functionality bones and ensure the restoration of bone tissue with reduced trauma surgery and a reduction in terms of rehabilitation, reduce the likelihood of recurrence of osteomyelitis.

 

1. A.s. № 700115 (SSSR) A61B17100, 1979 g.
2. Azolov V.V., Aleksandrov N.M., Alejjnikov A.V. Ispolzovanie loskutov s osevym krovosnabzheniem dlja ustranenija obshirnykh kostno-mjagkotkanykh defektov konechnostejj v uslovijakh izmenennogo recipientnogo lozha. // Tezisy dokladov VII sezda travmatologov-ortopedov Rossii. Novosibirsk. 2002. T.1. S. 378-379.
3. Batakov E.A., Ishutov I.V. Sovremennye aspekty kompleksnogo lechenija khronicheskogo osteomielita // Kazanskijj medicinskijj zhurnal. 2008. T. 89. № 1. S. 41-43.
4. Grigorovskijj V.V. Sovremennye predstavlenija o patologii i patanatomii gematogennogo osteomielita i ikh znachenie dlja klinicheskojj praktiki // Mezhdunarodnyjj medicinskijj zhurnal. 2003. № 1. S. 104-108.
5. Erjukhin I.A., Gelfand B.R., SHljap­nikov S.A.KHirurgicheskie infek­cii: Prakticheskoe rukovodstvo. M.: Littera. 2006. 736 s.
6. Kaplan A.V., Makhson N.E., Melnikova V.M.Gnojjnaja travmatologija kostejj i sustavov. M.: Medicina. 1985. 384 s.
7. Kononov V.S. Gematogennyjj osteomielit u detejj. M.: Medicina. 1974.
8. Nikitin G.D., Rak A.V., Linnik S.A. i dr.KHirurgicheskoe lechenie osteomielita. SPb: Rus. grafika. 2000. 287 s.
9. Onoprienko G.A., Buachidze O.SH., Erenin A.V., Savickaja K.I. i dr. KHirurgicheskoe lechenie bolnykh s khronicheskim gnojjnym porazheniem kostejj i krupnykh sustavov konechnostejj // KHirurgija. 2005. № 8. S. 29-35.
10. Sokolov V.A. Mnozhestvennye i sochetannye travmy. M.: GOEHTAR-Media. 2006. 512 s.
11. Cierny G. Chronic osteomyelitis: Results of treatment // Instr. Course Lect. 1990. V. 39.№ 1. P. 495-508.