A.A. Ol\'khov - Ph.D. (Eng.), Associate Professor, Head of the Laboratory, Department of Chemistry and Technology of Plastics and Plastic Composites, Moscow State University of Fine Chemical Technology names after M.V. Lomonosov, Moscow State University; Research Scientist, Institute of Chemical Physics RAS. E-mail: aolkhov72@yandex.ru E.D. Sklyanchuk - Dr.Sc. (Med.), Professor, Head of Orthopedic Department, Center of Traumatology and Orthopedics Road Clinical Hospital. N.A. Semashko at Lublino Station of «Russian Railways». E-mail: drevg@mail.ru T.A. Abbasov - Assistant, Department of Traumatology and Orthopedics, Moscow State Medical and Dental University named after A.I. Evdokimov. E-mail: tavriz28@mail.ru V.S. Akatov - Dr.Sc. (Phys.-Math.), Professor, Head of Laboratory of Tissue Engineering, Institute of Theoretical and Experimental Biophysics of the RAS. E-mail: v-akatoff@rambler.ru I.S. Fadeeva - Ph.D. (Biol.), Research Scientist, Laboratory of Tissue Engineering, Institute of Theoretical and Experimental Biophysics of the RAS. E-mail: aurin.fad@gmail.com R.S. Fadeev - Ph.D. (Biol.), Research Scientist, Laboratory of Tissue Engineering, Institute of Theoretical and Experimental Biophysics of the RAS. E-mail: fadeevrs@gmail.com N.I. Fesenko - Ph.D. (Biol.), Associate Professor, Training Center of Biophysics and Biomedicine of the Pushchino State Institute of Natural Science, Ministry of Education and Science. E-mail: fesenko.natalia@rambler.ru O.V. Staroverova - Post-graduate Student of Chemistry and Technology of Plastics and Plastic Composites, Moscow State University of Fine Chemical Technology named after M.V. Lomonosov; Junior Research Scientist, Institute of Chemical Physics RAS. E-mail: thalipha@mail.ru C.Z. Gumargalieva - Dr.Sc. (Chem.), Professor, Head of the Laboratory, Institute of Chemical Physics RAS. E-mail: guklara@yandex.ru Yu.N. Filatov - Dr.Sc. (Chem.), Professor, Head of the Center of Aerosols, SRC «Scientific Research Institute of Physical Chemistry them. LYa Karpova» . E-mail: filatov@electrospinning.ru A.L. Iordanskii - Dr.Sc. (Chem.), Professor, Head of the Laboratory, Institute of Chemical Physics RAS. E-mail: aljordan08@gmail.com V.V. Guriev - Dr.Sc. (Med.), Professor, Head of the Center of Traumatology and Orthopedics Road Clinical Hospital. N.A. Semashko at Lublino station of «Russian Railways». E-mail: drguriev@mail.ru

The development of implants that provide the regeneration of ligaments and tendons, there is an actual problem of modern traumatology and orthopedics. The paper presents an original artificial implant of ligaments developed using of solid polymeric fibers and non-woven matrix consisting of nano- and micro-fibers, made of polyhydroxybutyrate (PHB). It is shown that the nano- and microfiber PHB matrix of the implant exhibits a high biocompatibility, provides the attachment and growth of human cells thereon. It is found in an experimental model of Wistar rats that the implant exhibits the property of high effective conductor for regeneration of ligaments, particularly the damaged Achilles tendon. It is found also that the use of the nano- and microfibers in the implant is crucial for the formation of morphologically adequate tissue regenerate of the tendon in the tissue defect. The conclusion is made about high potential of the developed implant for reconstructive surgery

 

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