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Journal Technologies of Living Systems №5 for 2014 г.
Article in number:
The use of multielemental hair analysis for element status estimation in obesity
Keywords: obesity overweight potassium sodium magnesium calcium
Authors:
M.G. Skalnaya - Dr.Sc. (Med.), Professor, ANO «Center for Biotic Medicine», Moscow. Е-mail: skalnaya@yandex.ru
A.A. Tinkov - Post-graduate Student, Department of Biochemistry, Orenburg State Medical Academy. E-mail: tinkov.a.a@gmail.com
A.A. Nikonorov - Dr.Sc. (Med.), Professor, Head of Department of Biochemistry, Orenburg State Medical Academy. E-mail: nikonorov_all@mail.ru
A.V. Skalny - Dr.Sc. (Med.), Professor, Leading Research Scientist, Federal State Budgetary Scientific Institution «Institute of Toxicology» Federal Medico-Biological Agency, Saint Petersburg. Е-mail: skalny3@microelements.ru
Abstract:
The primary aim of the current study is to estimate the hair macroelement status in adult people in relation to body mass index (BMI) values. Materials and methods: 1229 persons living in Orenburg region took part in the investigation. Men and women were divided into 2 cohorts regarding the first and the second periods of adulthood. Every cohort was divided into 4 body weight groups (underweight, normal weight, overweight and obese). Hair macroelement content (μg/g) was estimated using inductively-coupled plasma mass-spectrometry. It is estimated that increased BMI values are accompanied by hair calcium and magnesium decrease. The level of these metals in hair significantly inversely correlated with BMI values. Hair sodium and potassium levels increased in groups with higher BMI. Hair K and Na significantly directly correlated with BMI values. The observed changes were more expressed in persons of the second period of adulthood when compared to the younger ones. Phosphorus hair content demonstrated a weak relationship with BMI values. Moreover, the changes were more expressed in women when compared to men. Generally, the results of the current study indicate the significant variation of elemental status of the body in the formation of obesity, which is accompanied by an increase in the content of some macronutrients and sharp decline in others. These facts indicate the significant role in favor of macrocells in the development of obesity but also in conjunction with existing literature data suggest that human organism macroelementoligy obesity status, at least partly, determine its relationship to other pathologies, in particular, insulin resistance, hypertension and dyslipidemia, which form the metabolic syndrome. At the same time, mechanisms of macronutrient content infringement in the body of persons suffering from overweight and obesity require a more detailed study.
Pages: 27-34
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