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Journal Technologies of Living Systems №4 for 2014 г.
Article in number:
Thermophysical modeling of cryosurgery with the case study of prostate cancer
Keywords: prostate cancer cryosurgery cryoablation prediction of temperature fields ansys
Authors:
A.O. Vasilyev - Post-graduate Student, Moscow State University of Medicine and Dentistry named after A.I. Evdokimov. E-mail: lexvasilyev@me.com
A.V. Govorov - Ph.D. (Med.), Assоciate Professor, Moscow State University of Medicine and Dentistry named after A.I. Evdokimov. E-mail: alexgovorov@newmail.ru
A.V. Pushkarev - Magister Department «E4», BMSTU, Engineer of 1st category, Department of Medical equipment, RMAPO. E-mail: pushkarev@bmstu.ru
D.I. Tsiganov - Dr. Sc. (Eng.) Professor, Head of Department «Medical equipment», RMAPO. E-mail: dtsiganov@yandex.ru
A.V. Shakurov - Magister Department «E4», BMSTU, Engineer Power Engineering Research Institute of the BMSTU. E-mail: shakurov@bmstu.ru
Abstract:
The clinical information about the usage of prostate cryoablation in the Russian Federation, highlights and disadvantages of cryosurgery are shown. A universal mathematical model describing the three-dimensional non-stationary processes of freezing of biological tissue is proposed. In particular, for the task of cryosurgical impact on pathological tissue in minimally invasive multiprobe surgery. On the basis of mathematical model were created algorithm and the original program of thermophysical modelling of cryosurgical exposure considering real thermophysical properties of biological tissue in a wide temperature range. For realization of specific features of the thermophysical model to effectively address a wide range of simulation problems was chosen software package ANSYS. In this case, numerical finite element method for unsteady problems applies. The specific formulation of the problem was considered. Three rows of three cryoprobes were included. We investigated two modes of cooling: (1) temperature of operating part of cryoprobe -80 °C cryoprobe and (2) -186 °C. As a result, the dependencies of the temperature distribution at the points on the border with the prostate gland in different directions were obtained. The regularities of formation of temperature fields and time of cryoablation in a particular formulation of the problem were found. An experimental study on the determination of the real temperature distribution on the surface of the cryoprobe was carried out. The minimum achieved temperature and the temperature distribution along the length of the working part of the cryoprobe were found. We have plans to hold series of computational experiments with a minimum of assumptions and to identify patterns of the cryonecrosis zone formation. The developed program can perform calculations not only for prostate cancer, but also for other bodies and create nomograms of optimal performance of cryoablation. Work provides a scientific basis for a finding of applied results. In the future, the final results of this study could be the basis for the creation of robotic surgical system with automatic feed of cryoprobes into specific points of the target zone for optimum mode of cryoablation. The reported study was partially supported by RFBR, research project No. 13-08-12051 ofi_m.
Pages: 47-53
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