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Journal Technologies of Living Systems №4 for 2014 г.
Article in number:
Features of biosubstrates element composition of organism as evidence of adaptation to changing conditions
Keywords: laboratory animals adaptation thyroid chemical elements artificial hyperthyroidism artificial hypothyroidism
Authors:
S.V. Notova - Dr.Sc. (Med.), Professor, Department of Biochemistry and Molecular Biology, Orenburg State University
S.V. Miroschnikov - Ph.D. (Med.), Assistant, Department of Surgery, Orenburg State Medical Academy
E.S. Barysheva - Dr.Sc. (Med.), Professor, Head of the Department of Biochemistry and Molecular Biology, Orenburg State University
I. E. Alidzhanova - Dr.Sc. (Med.), Head of the Laboratory, Institute of Micro and Nanotechnology, Orenburg State University
Abstract:
This article is devoted to the study of the elemental exchange features of laboratory animals under the influence of artificial hyperthyroidism and hypothyroidism. The study was performed on 45 male laboratory rats " Wistar ", their weight was between 100 and 250 grams. To study the elemental composition samples of thyroid tissue, hair and the body of an average sample were used. Using mass spectrometry and atomic emission spectrometry with inductively coupled argon plasma content of 25 chemical elements was investigated. It was found that content most of the chemical elements depend on the activity of thyroid gland functioning. The level of iodine concentration in the thyroid gland reduced by 2 times under the influence of thyrotoxicosis and reduced by 6 times under the influence of hypothyroidism compared with the concentration in the body. The relative concentration of Se and Zn in the thyroid gland decreased in thyrotoxicosis and increased in hypothyroidism. Under the influence of thyrotoxicosis or hypothyroidism Ca and Sr concentration in the thyroid gland increased; B, Cu and Cd concentration in the thyroid gland decreased. The data obtained clearly demonstrate the influence of thyroid status on mineral metabolism and adaptive nature of chemical elements redistribution in the body.
Pages: 21-24
References

  1. Agadzhanyan N.A., Notova S.V. Stress, fiziologicheskie i ekologicheskie aspekty adaptatsii putem korrektsii. Orenburg: OGU. 2009. 274 s
  2. Dzhazaerli M.S., Davydov V.V. Vozrastnye osobennosti izmeneniya kontsentratsii tireoidnykh gormonov v krovi pri intensivnoy fizicheskoy nagruzke u krys s eksperimental'nym gipotireozom. Khar'kov: Khar'kovskaya meditsinskaya akademiya poslediplomnogo obrazovaniya. Institut okhrany zdorov'ya detey i podrostkov AMN Ukrainy. 2006. S. 156-138.
  3. Ivanov S.I., Podunova L.G., Skachkov V.B. i dr. Opredelenie khimicheskikh elementov v biologicheskikh sredakh preparatakh metodami atomno-emissionnoy spektrometrii s induktivno svyazannoy plazmoy i mass-spektrometriey: Metodicheskie ukazaniya (MUK 4.1.11482-03, MUK 4.1.1483-03). M.: FTsGSEN MZ RF. 2003. 56 s.
  4. Miroshnikov S.V., Notova S.V., Kvan O.V.  Osobennosti adaptatsionnykh reaktsiy u lits s vysoko- i nizkonormal'nym urovnem tireotropnogo gormona, prozhivayushchikh na territorii endemichnoy po zobu // Vestnik OGU. 2011. № 12. S. 293-297.
  5. Radysh I.V., Bryunin D.V., Umnova T.N. Izmenenie gormonal'nogo i elementnogo profilya u zdorovykh zhenshchin // Tekhnologii zhivykh sistem. 2012. T .9. № 1. S. 61-64.
  6. Suslikov V.L. Geokhimicheskaya ekologiya bolezney. Ateroskleroz. T. IV. Cheboksary: Izd-vo Chuvash. un-ta. 2011. 380 s.
  7. Trush V.V., Sobolev V.I. Izmenenie silovykh kharakteristik skeletnoy myshtsy beloy krysy v protsesse uglubleniya eksperimental'nogo gipertireoza // Arkhiv klinicheskoy i eksperimental'noy meditsiny. 2003. T. 21 № 4. S. 144-149.