O.V. Staroverova, A.M. Shushkievich, G.M. Kuz'micheva, A.A. Olhov, V.V. Voinova, I.I. Zharkova, K.V. Shaitan, E.D. Sklyanchuk, V.V. Guriev

The article is devoted to the creation of non-woven fibrous scaffolds as promising materials for tissue-ingeneering designs. At the core of the development of non-woven material used method elektrospinning of the forming solution of poly-3-hydroxybutyrate, which biodegrade in tissues with non-toxic products The forming or the fibous material using chloroform, formic acid, with the inclusion of titanium dioxide and tetrabutylammonium iodide (TBAI) at different concentrations of poly-3-hydroxybutyrate (PHB) in the forming solution is described in the research. The structure of the composite scaffolds examined by light and electron miroskopii. Their physical-mechanical characteristics evaluated on a tensile testing machine. To assess biocompatibility used cultivation method on the surface of the matrix of human mesenchymal stem cells. The study revealed a clear dependence of the characteristics of the composite from the procedures used where found that the highest tensile strength and packing density of fibers, together with the smallest fiber diameter gain fibrous materials with the addition of TBAI and TiO2 into the forming solution. In assessing the biocompatibility of the best indicators also had composites with these additives. Non-woven fibrous matrices on the basis of poly-3-hydroxybutyrate obtained by electrospinning with the addition of TBAI and titanium dioxide can be recommended for growing MSCs with the prospect of their use in tissue engineering.