L.V. Antonova, A.S. Golovkin, D.E. Philipjev, Y.G. Toropova, V.G. Matveeva, E.A. Velikanova, V.V. Borisov, Y.A. Kudryavtseva, T.V. Glushkova

Designing a hybrid vascular graft using biocompatible and biodegradable polymers is one of the ways to fill the market with vascular grafts of a small diameter necessary for coronary artery bypass surgery. Good adhesive properties of cultivated cells and low cytotoxicity of biopolymers can improve biocompatibility of polymer-based vascular grafts. Copolymeric tubular designs on the basis of composition of 5% of polyhydroxybutirate with hydroxyvalerate/10% polycaprolactone were made of electrospinning-method. We studied physicomechanical characteristics of the received designs and their biocompatibility of in vitro. By preliminary results of physicomechanical tests copolymeric tubular scaffolds showed higher elastic-deformativity properties, than the native vessels for coronary artery bypass surgery. High porosity of an internal surface allowed to create a cellular monolayer on the basis of multipotent mesenchymal stromal cells of bone marrow and human umbilical vein endothelial cells in short terms. Decrease of cellular viability it isn't registered after interaction of cages with a surface nonwoven scaffolds.