D.N. Kushlinsky, I.V. Tereshkina, N.V. Levkina, Yu.V. Kryuk

Degradation of surrounding basal membrane and extracellular matrix (ECM) by tumor-associated proteases is considered to be one of the main mechanisms regulating tumor invasion and metastasizing. It is known that matrix metalloproteases (MMP) ? a family of more than 20 secreted and cell surface-bound Zn-dependent endopeptidases capable to hydrolyze practically all ECM components - are involved in all stages of tumor progression. This review presents information about MMPs and their tissue inhibitors (TIMPs) properties and mechanisms of action, as well as about their associations with ovarian neoplasms main clinical and morphologic features (tumor process advancement, tumor histological structure and differentiation), and prognosis. In addition, new specific inhibitors with specificity to definite MMP types are now under development. Hence, the study of MMPs and TIMPs expression spectrum, levels and ratio, and their biological and prognostic value may become useful for the development and successive application of new MMP inhibitors specific for ovarian cancer or for an individual patient.

 

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