350 rub
Journal Technologies of Living Systems №9 for 2012 г.
Article in number:
Prevention of abnormalities of hemostasis and vte in ovarian cancer patients, undergoing chemotherapy
Keywords: ovarian cancer hemostasis thrombosis LMWH
Authors:
O.V. Somonova, A.V. Madzhuga, A.L. Elizarova, D.N. Kushlinskii, I.I. Matveeva
Abstract:
Cancer tumor elevates risk of venous thromboembolism (VTE) and pulmonary embolism in 4 - 7 time. Abnormalities of hemostasis system, activate tumor and chemotherapy, plays base role in pathogenesis of VTE in ovarian cancer patients. The use of LMWH in chemotherapy reduces the activation of pro-coagulation (aPTT, prothrombin, von Willebrand factor) and platelet links of hemostasis system. LMWH conduces preservation of natural inhibitor of thrombin, maintains the defensive role of fibrinolysis. The VTE was 22 % in the control group and 5 % in the LMWH group. Rise of concentration of fibrinogen, D-dimer, von Willebrand factor are hemostasis factors prognosis of development cancerous process.
Pages: 43-47
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