350 rub
Journal Technologies of Living Systems №9 for 2012 г.
Article in number:
Insulin-like growth factors 1 and 2, and insuline-like growth factor binding proteins 1 and 3 in bone tumors
Keywords: insulin-like growth factors (IGF-1 IGF-2) insuline-like growth factor binding proteins (IGFBP-1 IGFBP-3) bone tumors
Authors:
Yu.S. Timofeev, N.E. Kushlinskii, I.V. Babkina, O.I. Kostyleva, I.V. Boulytcheva, I.N. Kuznetsov, Yu.N. Soloviev, M.D. Aliev
Abstract:
Insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) and insulin-like growth factor binding proteins IGFBP-1, IGFBP-3 were measured by ELISA techniques in blood serum of 113 patients with primary bone tumors. A significant increase of serum IGF-1, 2 and IGFBP-1, 3 levels of bone tumor patients as compared to control group was found; serum IGF-1, 2 levels were significantly increased in malignant bone tumor patients as compared to those with benign neoplasms, and IGFBP-3 levels were increase in benign tumor patients as compared to malignant bone tumor and control groups. Significant differences in markers - levels depending on malignant tumor histological type were revealed.
Pages: 33-37
References
  1. Clemmons D.R. Value of insulin-likegrowth factor system markers in the assessment of growth hormone status // Endocrinol. Metab. Clin. North. Am. 2007. V. 36. P. 109 - 129.
  2. Frystyk J. Free insulin-like growth factors -Measurements and relationships to growth hormone secretion and glucose homeostasis // Growth Horm. IGF Res. 2004. V. 14. P. 337 - 375.
  3. Vardatsikos G., Sahu A., Srivastava A.K. The Insulin-Like Growth Factor Family: Molecular Mechanisms, Redox Regulation, and Clinical Implications, antioxidants & redoxsignaling // Mary Ann Liebert, Inc. 2009. V. 11. № 5. P.1165.
  4. Dupont J., Pierre A., Froment P., Moreau C. The insulin-like growth factor axis in cell cycle progression // Horm. Metab. Res. 2003. V. 35.  P. 740-750.
  5. Zhuang D., Ceacareanu A.C., Lin Y., Ceacareanu B., Dixit M., Chapman K.E., Waters C.M., Rao G.N., Hassid A. Nitric oxide attenuate sinsulin-or IGF-I-stimulated aortics mooth muscle cell motility by decree sing H2O2 levels: Essential role of cGMP // Am. J. Physiol. Heart Circ. Physiol. 2004. V. 286. P. H2103 - H2112.
  6. Fukuda R., Hirota K., Fan F., Jung Y.D., Ellis L.M., Semenza G.L. Insulin-like growth factor 1 induces hypoxia-inducible factor1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells // J. Biol. Chem. 2002. V. 277. P. 38205 - 38211.
  7. Conover C.A. Insulin-like growth factor-binding proteins and bone metabolism // Am. J. Physiol.
    Endocrinol. Metab. 2008. V. 294. P. E10-14.
  8. Ulaner G.A., Vu T.H., Li T., Hu J.F., Yao X.M., Yang Y. Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site // Hum. Mol. Genet. 2003. V. 12. P. 535 - 549.
  9. Riggi N., Cironi L., Provero P., Suva M.L., Kaloulis K., Garcia-Echeverria C. Development of Ewing-s sarcoma from primary bone marrow-derived mesenchymal progenitor cells // Cancer Res. 2005. V. 65. P. 11459 - 11468.
  10. Kageyama K., Moriyama T., Hizuka N., Sakihara S., Takayasu S., Tamasawa N., Suda T. Hypoglycemica Associated with Big Insulin-Like Growth Factor II Produced during Developmen of Malignant Gibrous Hisiocytoma // End. J. 2003. V. 50. № 6. P. 753 - 758.
  11. Rikhof B., de Jong S., Suurmeijer A.J., Meijer C., van der Graaf W.T. The insulin-like growth factor system and sarcomas // J. Pathol. 2009. V. 217. P. 469 - 482.
  12. Samani A.A., Yakar S., Le Roith D., Brodt P. The Role of the IGF System in Cancer Growth and Metastasis: Overview and Recent Insights // Endocrine Reviews. 2007. V. 28. № 1. P. 20 - 47.
  13. Tang Y., Zhang D., Fallavollita L., Brodt P. Vascular endothelial growth factor C expression and lymph node metastasis are regulated by the type I insulin-like growth factor receptor // Cancer Res. 2003. V. 63. P. 1166 - 1171.
  14. Firth S., Baxter R. Cellular Actions of the Insulin-Like Growth Factor Binding Proteins // Endocrine Reviews. 2002. V. 23. P. 824 - 854.