350 rub
Journal Technologies of Living Systems №6 for 2012 г.
Article in number:
Soluble form of adhesion molecules vascular endothelial one (sVCAM-1) in patients with bone tumors
Keywords: sVCAM-1 osteosarcoma chondrosarcoma blood serum
Authors:
I.V. Babkina, E.Yu. Russo, Yu.N. Soloviev, I.N. Kuznetsov, E.A. Ten, M.D. Aliev
Abstract:
Results of the comparative analysis of sVCAM-1 levels in blood serum for 50 apparently healthy people, 152 patients with malignant tumors and 14 patients with borderline tumors of bone are presented, taking into account main clinical and morphological characteristics of the desease. The average content of sVCAM-1 in blood serum for patients with neoplasms of bones was authentically higher than that for healthy people. There were no differences between sVCAM-1 contents for borderline and malignant bone tumors. Authentical dependeces of sVCAM-1 content in blood serum were not identified in patients with respect to their age and type of affected bones and any interconnction between tumor size and sVCAM-1 level in blood did not revealed. During the initial examination, sVCAM-1 levels in blood serum for patients with positive effect from chemotherapy treatment corresponding to the 3rd or 4th degrees of the treatment pathomorphosis tumor were lower than those for patients which noted resistance to chemotherapy or for the 2nd degree of the treatment pathomorphosis. Possible role of sVCAM-1 in the bone malignant tumor pathomorphosis is discussed.
Pages: 64-68
References
  1. Corradi D., Wenger D.E., Bertoni F. et al. Multicentric osteosarcoma: clinicopathologic and radiographic study of 56 cases // Am. J. Clin. Pathol. 2011. V. 136. № 5. P. 799-807.
  2. Deneva-Koycheva T.I., Vladimirova-Kitova L.G., Angelova E.A., Tsvetkova T.Z. Serum levels of siCAM-1, sVCAM-1, sE-selectin, sP-selectin in healthy Bulgarian people // Folia Med (Plovdiv). 2011. V. 53. № 2. P. 22-28.
  3. Eggeman H., Stöblen F., Thill M. et al. Influence of a
    dose-dense adjuvant chemotherapy on sVCAM-1/sICAM-1 serum levels in breast cancer patients with 1-3 positive lymph nodes // Anticancer Res. 2011. V. 31. № 8. P. 2617-2622.
  4. Landt S., Wehling M., Heidecke H. et al.Prognostic significance of angiogenic factors in uterine cervical cancer // Anticancer Res. 2011. V. 31. № 8. P. 2589-2595.
  5. Mantur M., Snarska J., Koper O. et al. Serum sICAM, sVCAM and sE-selectin levels in colorectal cancer patients // Folia Histochem. Cytobiol. 2009. V. 47. № 4. P. 621-625.
  6. Rutkowski P., Kaminska J., Kowalska M. et al.Cytokine and cytokine receptor serum levels in adult bone sarcoma patients: correlations with local tumor extent and prognosis // J. Surg. Oncol. 2003. V. 84.№ 3. P. 154-159.
  7. Sampo M., Koivikko M., Taskinen M. et al. Incidence, epidemiology and treatment results of os
    teosarcoma in Finland - a nationwide population-based study // Acta Oncol. 2011. V. 50. № 8. P. 1206-1214.
  8. Shariat S.F., Anwuri V.A., Lamb D.J. et al. Association of preoperative plasma levels of VEGF and soluble vascular cell adhesion molecule-1 with lymph node status and biochemical progression after radical prostatectomy // J.Clin.Oncol. 2004. V. 29. № 9. P. 1655-1663.