350 rub
Journal Technologies of Living Systems №3 for 2012 г.
Article in number:
Clinical and biochemical aspects of carcinoid syndrome in neuroendocrine tumors in peritoneal and retro peritoneal cavities
Keywords: neuroendocrine tumor carcinoid syndrome serotonin catecholamines
Authors:
S.B. Polikarpova, A.S. Ogerelev, A.T. Kokolishvili, N.I. Borovskaya
Abstract:
We present study overall and disease free survival of 238 patients with neuroendocrine tumors with and without carcinoid syndrome. Carcinoid syndrome rate was 15,6 %. There was no relationship between carcinoid syndrome and overall and disease free survival. Patients with carcinoid syndrome had low disease free survival. The diarrhea was a factor of unfavorable outcome. The data obtained demonstrated that the early time manifestation of carcinoid syndrome was indicator of unfavorable prognosis in patients with malignant neuroendocrine tumors. Patients with pheochromocytoma and paraganglioma presented relationship between urinary catecholamines and carcinoid syndrome. There was relationship between adrenaline, noradrenaline and dopamine urinary excretion (r = 0,53; р < 0,05).
Pages: 37-42
References
  1. Wheeler M.H., Maddox P., Maddineni S., Jordan S., Amer K., Butchart E. Surgical treatment of carcinoid tumours // Przegl. Lek. 2000. V. 57(Suppl. 5). P. 95 - 97.
  2. Hu Y.Q., Qian J.M., Zhou X.D. Comparison and analysis of the clinical features of different types of gastrointestinal cancers // Zhonghua Nei Ke Za Zhi. 2004. V. 43(12). P. 900 - 902.
  3. Neary P.C., Redmond P.H., Houghton T., Watson G.R., Bouchier Hayes D. Carcinoid disease: review of the literature // Dis. Colon Rectum. 1997. V. 40(3). P. 349 - 362.
  4. Saslow S.B., Camilleri M., Thomforde G.M., Van Dyke C.T., Pitot H.C., Rubin J. Relation between fat malabsorption and transit abnormalities in human carcinoid diarrhea // Gastroenterology. 1996. V. 110(2). P. 405 - 410.
  5. Gough D.B., Thompson G.B., Crotty T.B., Donohue J.H., Kvols L.K., Carney J.A., Grant C.S., Nagorney D.M. Diverse clinical and pathologic features of gastric carcinoid and the relevance of hypergastrinemia // World J Surg. 1994. V. 18(4). P. 473 - 479.
  6. Hegde V., Mohandas K.M., Ramadwar M., Shukla P., Mehta S. Gastric carcinoids - a changingtrend // Indian J. Gastroenterol. 2003. V. 22(6). P. 209 - 211.
  7. Burke A.P., Thomas R.M., Elsayed A.M., Sobin L.H. Carcinoids of the jejunum and ileum: an immunohistochemical and clinicopathologic study of 167 cases // Cancer. 1997. V. 79(6). P. 1086 - 1093.
  8. Maurer C.A., Baer H.U., Dyong T.H., Mueller G.E., Friess H. et al. Carcinoid of the pancreas: clinical characteristics and morphological features // Eur. J. Cancer. 1996. V. 32A(7). P. 1109 - 1116.
  9. Davis K.P., Hartmann L.K., Keeney G.L., Shapiro H.Primary ovarian carcinoid tumors // Gynecol. Oncol. 1996. V. 61(2). P. 259 - 265.
  10. Soga J., Osaka M., Yakuwa Y. Carcinoids of the ovary: an analysis of 329 reported cases // J. Exp. Clin. Cancer Res. 2000. V. 19(3). P. 271 - 280.
  11. Soga J. Carcinoids of the rectum: an evaluation of 1271 reported cases // Surg. Today. 1997.  V.27(2). P. 112 - 119.
  12. Argani P., van Hoeven K.H., Artymyshyn R.L.Diagnosis of metastatic appendiceal adenocarcinoid in liver by fine-needle aspiration cytology // Diagn. Cytopathol. 1995. V. 12(1). P. 59 - 61.
  13. Deans G.T., Spence R.A. Neoplastic lesions  of the appendix // Br. J. Surg. 1995. V. 82(3). P. 299 - 306.
  14. Stinner B., Kisker O., Zielke A., Rothmund M.Surgical management for carcinoid tumors of small bowel, appendix, colon, and rectum // World J. Surg. 1996. V. 20(2). P. 183 - 188.
  15. Andjelkovic Z., Tavcar I. Personal experience in diagnosis and localization of Pheochromocytoma // Srp. Arh. Celok. Lek. 2002. V. 130. Suppl. 2. P. 14 - 19.
  16. Noshiro T., Shimizu K., Watanabe T., Akama H., Shibukawa S., Miura W., Ito S., Miura Y. Changes in clinical features and long-term prognosis in patients with pheochromocytoma // Am. J. Hypertens. 2000. V. 13(1 Pt. 1). P. 35 - 43.