350 rub
Journal Technologies of Living Systems №3 for 2012 г.
Article in number:
Leucocyte integrins expression and some serum cytokines levels correction by phytoadaptogene in mice with spontaneous hepatomas
Keywords: spontaneous hepatocarcinogenesis leucocyte integrins cytokines multiphytoadaptogene
Authors:
O.A. Bocharova, R.V. Karpova, V.A. Ilyenko, E.V. Bocharov, I.V. Kazeev, A.Y. Baryshnikov
Abstract:
The aim of this study was leucocyte integrins LFA-1 and Mac-1 expression on blood lymphocytes as well as IL-6 and IL-10 serum levels analysis in males of inbred mice CBA (n=170) susceptible to spontaneous hepatomas. LFA-1 and Mac-1 expression reducing, IL-6 and IL-10 blood serum levels uncreasing were observed during mice ontogenesis. The alterations of these parameters by means of preventive and curing multiphytoadaptogene per os administration (with drinking water) was evaluated. The results suggest that leucocyte integrins levels correction enhances the expression of adhesive ligands (ICAM-1, 2) for immune effectors (in tumors) which are able to kill cancer cells increasing antitumor inspection in the organism.
Pages: 13-17
References
  1. Lascombe I., Clairotte A., Fauconnet S., Bernardini S., Wallerand H., Kantelip B., Bittard H.
    N-cadherin as a novel prognostic marker of progression in superficial urothelial tumors // Clin Cancer Res. 2006. V. 12. № 9. P. 2780 - 2787.
  2. Хаитов Р.М., Ярилин А.А., Пинегин Б.В. Иммунология: атлас. М.:ГЭОТАР-Медиа. 2011. 624 с.
  3. Kawaguchi T. Cancer metastasis: characterization and identification of the behavior of metastatic tumor cell and the adhesion molecules, including carbohydrates // Curr. Drug. Targets. Cardiovasc. Haematol. Disord. 2005. V. 5. № 1. P. 39 - 64.
  4. Hynes R.The extracellular matrix: not just pretty fibrils // Science. 2009. V. 326. Р. 1216 - 1219.
  5. Kadioglu A., De Filippo K., Bangert M. The integrins Mac-1 and alpha4beta1 perform crucial roles in neutrophil and T cell recruitment to lungs during Streptococcus pneumoniae infection // J. Immunol. 2011. V. 186. № 10. Р. 5907 - 5915.
  6. Kim D., Oh S., Kwon H., Lee S. Clinical significance of preoperative serum interleukin-6 and C-reactive protein level in operable gastric cancer // Cancer. 2009. V. 20. № 9. Р. 155 - 161.
  7. Барышников А.Ю., Демидов Л.В., Кадагидзе З.Г. Современные проблемы биотерапии злокачественных опухолей // Вестник московского онкологического общества. 2008.
    № 1. С. 6 - 10.
  8. Fillon M.Biomarkers and prostate cancer progression // J. Natl. Cancer Inst. 2011. V. 103. № 21. Р. 1570 - 1571.
  9. Liang J.T., Wang Z.Y. Serum levels of interferon-γ, interleukin-6 and tumor necrosis factor-α in patients with cerebral arterial stenosis // Beijing Da Xue Xue Bao. 2011. V. 43. № 6. Р. 837 - 840.
  10. Kim S. Kwon H., Chi D., Shim J., Park J., Lee Y., Pyo S., Rhee D. Reversal of P-glycoprotein-mediated multidrug resistance by ginsenoside Rg(3) // Biochem. Pharmacol. 2003. V. 65.
    Р. 75 - 78.
  11. Guo L., Song L., Wang Z. Panaxydol inhibits the proliferation and induces the differentiation of human hepatocarcinoma cell line HepG2 // Chem. Biol. Interact. 2009. V. 181.
    № 1. Р. 138 - 143.
  12. Бочарова О.А., Барышников А.Ю., Давыдов М.И. Фитоадаптогены в онкологии и геронтологии // М.: МИА. 2008. 218 с.
  13. Eukaszewicz M., Mroczko B., Szmitkowski M. Clinical significance of interleukin-6 (IL-6) as a prognostic factor of cancer disease // Pol. Arch. Med. Wewn. 2007. V. 117. № 5 - 6. P. 247 - 251.
  14. Brady J., Carotta S., Thong R. еt al. The interactions of multiple cytokines control NK cell maturation // J. Immunol. 2010. V. 185. № 11.
    Р. 6679 - 6688.
  15. Sasada T., Suekane S.Variation of tumor-infiltrating lymphocytes in human cancers: controversy on clinical significance // Immunotherapy. 2011. V. 3. № 10. Р. 1235 - 1251.