V.M. Gorshkova, S.V. Savchenko

Currently the problem of increasing the pain barrier has become acute in many fields of medicine. Abating strong pains permits to relieve a patient's negative attitude to different injections recom-mended for treatment during intensive care (after surgical operations during a rehabilitation period of grown-ups and children), during therapeutic treatment of different diseases by hypodermic injections. At present in view of the rapid development of the aesthetic medicine (mesotherapy, peeling, hypodermic injections of medical products - botex etc.) patients suffer from strong sensa-tions of pain which can and must be get rid of. The investigations to cope with this problem are carried out in the Ultrasonic laboratory of the Bauman Moscow State Technical University (MSTU). Injecting pharmaceutical substances by ul-trasonic is phonophoresis, which has been studied at the MSTU for more than 20 years, different technologies to apply it are created and good results achieved. The biological effect of ultrasonic is known primarily as regards the processes determining permeability of biological structures and transport through membranes. Ultrasonic increases the permeability of skin, vessels and cell membranes, and mass transfer of substances through them is intensified. Mechanical loosening of conjunctive tissue and depolarization of hyaluronic acid play an important role in the increase of permeability occurring at insonation. Both acceleration of active transport and increase in mass transfer by concentration gradient form the basis of the biological structures permeability growth under the influence of ultrasonic. Transfer of a pharmaceutical substance within the ultrasonic - biological tissue area results from physical properties of the ultrasonic itself. When ultrasonic waves are passing through a pharmaceutical substance, oscillating particles of the medium cause both an acoustic live pressure and a change of pressure in the substratum against the environmental pressure. This is a radiation (constant) pressure. Live and radiation acoustic pressures influence not only a morphofunctional status of the membrane but the ability of fluid and substances to transfer and redistribute between the cells and the surrounding environment.