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Journal Technologies of Living Systems №8 for 2009 г.
Article in number:
RESEARCH OF INTERRELATION OF DEATH RATE FROM THE SUICIDE WITH PHENOTYPE NAT2 AND GEOGRAPHICAL COORDINATES OF VARIOUS ETHNIC POPULATIONS OF THE WORLD
Authors:
L.A. Piruzjan, K.S. Gjulazizova, I.S. Nikolaeva, A.S. Kabankin, A.R. Kuznetsova, A.D. Radkevich, A.D. Pynko, G.P. Suhinina, L.A. Radkevich
Abstract:
By us it is established that average indexes suicide mortality rate coefficient (SMRC) in populations with prevalence of phenotype NAT2 slow acetylator it is essential above SMRC from a suicide in populations with prevalence of phenotype NAT2 fast acetylator especially at men (Drawing 1). Further we had been investigated interrelation between geographical width and frequency of oc-currence (FO) phenotype NAT2 fast acetylator in 76 ethnic populations. On Table 1 it is visible that the correlation factor (r) between geographical width and FO phenotype NAT2 fast acetylator negative and is equal - 0,714 (р <0,01) (Table 1). It testifies that, ethnoses with high FO phenotype NAT2 fast acetylator are located more close to equator, and at the ethnoses located further from equator, prevail NAT2 slow acetylator. Between FO phenotype NAT2 fast acetylator and a geo-graphical longitude we establish positive connection (r = 0,765; р < 0,01) (Table 1). So in the eth-noses located between Greenwich meridian on the northeast to 40th degree of east longitude, pre-vail NAT2 slow acetylator. After 40 degrees of east longitude in ethnoses FO NAT2 fast acetylator starts to prevail. At interrelation research between SMRC from a suicide and geographical width at 90 ethnic populations (Table 1) it is visible that the correlation factor (r) is equal 0,682 at men and 0,573 at women (р <0,001). At interrelation research between (SMRC) from a suicide and a geographical longitude at 90 ethnic populations (Table 1) it is visible that the correlation factor (r) is equal-0,550 at men and-0,532 at women (р <0,001). On the basis of the given researches it is possible to conclude that the ethnoses located to the north of 29th degree of northern width in East hemisphere (Europe) and to the north of 26th degree in the Western hemisphere, belong to big европеоидной to race. ЧВ phenotype БА at these ethnic populations makes 20-46 %, i.e. at them prevail NAT2 slow acetylator. SMRC from a suicide at men averages 25,09 on 100000 standardised population. The ethnoses located to the south of 54th degree of northern width in Asia and belonging to big монголоидной and австралоидной to the race, and also to transitive and in-termediate types between монголоидной and австралоидной races, have as a part of populations of 70-90 % NAT2 fast acetylator. In these ethnoses SMRC from a suicide at men averages 14,7 on 100000 standardised population. An exception represent Australia with FO NAT2 fast acetylator of 43 % who has КС 21,4 on 100000 standardised population, and New Zealand with FO NAT2 fast acetylator of 38 % and SMRC equal 22,8 on 100000 standardised population. However it is known that as a part of ethnoses of these countries the considerable share is made by descendants of the European immigrants belonging mainly to phenotype NAT2 slow acetylator. In the western hemisphere the ethnoses located to the south of 26th degree of northern width, concern to big mongolian to race (Indians), and also transitive and intermediate types white, mongolian and black races. At them prevail NAT2 fast acetylator with low SMRC from a suicide (Vest India and Latin America). For example, in Costa Rica with FO NAT2 fast acetylator of 62 % SMRC from a suicide at men makes 6,8 on 100000 standardised population, in Mexico with FO NAT2 fast acetylator of 70 % SMRC from a suicide at men it is equal 5,94 persons on 100000 standardised population, i.e. SMRC from a suicide in these countries in 2-3 times more low, than in populations with advantage NAT2 slow acetylator. In the North America at the ethnoses located more close to Greenwich meridian, above frequency of occurrence of a phenotype slow N-atsetilirovanija (white Americans, Canadians). In central and the South America, at removal from Greenwich meridian (from 54th degree of the western longitude) in populations prevail NAT2 fast acetylator (Latin Americans, Indians). As acknowledgement of results of research we have analysed SMRC from a suicide at men and women in age groups from 0 to 75 + in 6 countries. By comparison SMRC from a suicide in Russia and in South Korea (Drawing 2а and 2b) it is visible that in Russia death rate from a suicide at men considerably above, than in South Korea. By comparison SMRC from a suicide at men in Finland and Singapore (Drawing 3а and 3b) it is visible that death rate from a suicide at men in Finland it is considerable above, than in Singapore. By comparison SMRC from a suicide at men in Canada and Venezuela (Drawing 4а and 4b), high sizes SMRC from a suicide in Canada in comparison with Venezuela also are found out. Women SMRC from a suicide have less, than at men (factor 1:4) that testifies to gender distinctions. But the tendency remains to the same. Death rate from a suicide at women in Russia, Finland, Canada above, than in South Korea, Singapore, Venezuela. It is known, what FO phenotype NAT2 fast acetylator in Russia - 45 %, in Finland - 36 %, in Canada - 42 %, whereas in South Korea ЧВ of phenotype БА of 90 %, Singapore - 81 %, Venezuela - 70 %. Geographical position of Russia - 62,5о northern width, Finland - 64,5о northern width, Canada - 63о northern width (the central points). The Geographical position of South Korea 39о northern width, Singapore 12,5о northern width, Venezuela 7о northern width (the central points) (table 1).Таким in the image, these examples once again confirm that in the countries located in northern widths, to the north 47о northern width, ethnoses with phenotype NAT2 slow acetylator and high death rate from a suicide, especially at men prevail. In the countries located, to the south 39о northern width, ethnoses with phenotype NAT2 fast acetylator and low death rate from a suicide prevail. It is necessary to notice that death rate from a suicide does not depend on a standard of living in above listed countries.
Pages: 33-45
References
  1. Дюркгейм Э.Самоубийство: Социологический этюд. 1897 г. / пер. с франц. А.Н. Ильинского. СПб.: Союз. 1998.
  2. Зиновьев С.В.Суицид. Попытка системного анализа. СПб.:. 2002. 135 с.
  3. Красненкова И.П.// Вестн. Моск. Ун-та. Сер. 12, Политические науки. 1998. № 6. С.18-33. LesterD. // Seasonalvariationsinsuicide deaths // British Journal of Psychology. 1971. V. 118. № 4. P. 627 - 628
  4. Мягков А.Ю.Темпоральные характеристики самоубийств //Социологические исследования. 2004. № 3. С. 83 - 92.
  5. Янковский Н.К., Боринская С.А. Наша история, записанная в ДНК // Природа. 2001. № 6.
  6. Morselli H.1882. Suicide: An Essay on Comparative Moral Statistics. N.Y.: D. Appleton and Co.
  7. Kevan S. Perspectives on season of suicide: A review // Social Science and Medicine. 1980. V. 14. № 3. P. 369-378.
  8. Maldonado G., Kraus J.F. Variation in suicide occurrence by time of the day, day of the week, month and lunar phase // Suicide and Life-Threatening Behavior. 1991. V. 21. №2. P. 174-188.
  9. Hassan R. Temporal variations in suicide occurrence in Australia: A Research Note // Australian and New Zealand Journal of Sociology. 1994. V. 30. № 2. P. 194.
  10. Радкевич Л.А., Гюльазизова К.С.,Нечаев Д.С., Сошинский И.С., Николаева И.С., Крылов Е.Н., Пирузян Л.А. Исследование взаимосвязи полиморфизма фенотипа NAT2 с предрасположенностью к суициду в этнических популяциях. 2005. ДАН. Т. 404. № 1. С. 177-122.
  11. Ralph J. Delfino, Rashmi Sinha, Cynthia Smith, John West, Edward White, Henry J. Lin, Shu-Yuan Liao, Jason S.Y. Gim, Hoang L. Ma, John Butler and Hoda Anton-Culver. Breast cancer, heterocyclic aromatic amines from meat and N-acetyltransferase 2 genotype //Carcinogenesis. 2000 April;V. 21. No. 4.Р. 607-615, 
  12. McLeod HL, PGENI Project
  13. http://pgeni.im.wustl.edu/gene.asp-gid=573
  14. Hein D.W., McQueen C.A., Grant D.M., Goodfellow G.H., Kadlubar F.F., Weber W.W. Pharmacogenetics of the arylamine N-acetyltransferases: a symposium in honor of Wendell W. Weber // Drug. Metab. Dispos. 2000 Dec. V. 28(12). P.1425-32.
  15. Ognjanovic S, Yamamoto J, Maskarinec G, Le Marchand L. NAT2, meat consumption and colorectal cancer incidence: an ecological study among 27 countries // Cancer Causes Contro.l. 2006. V. 17. P. 1175-1182.
  16. Sotiria B., Giannoulis F. Arylamine N-Acetyltransferases: What We Learn from Genes and Genomes. Drug Metabolism Reviews. 2000. 537. V.3.P.511 - 564.
  17. Пирузян Л.А. // Вестник РАН. 2004. Т.74. №7.С.610-615
  18. Пирузян Л.А. // Известия Акад. Наук. Сер. биол. 1990. № 2. С.302-303.
  19. Пирузян Л.А., Радкевич Л.А., Морозова Н.В. // ДАН. 2003. Т. 388. № 6. С. 842-846.
  20. Радкевич Л.А., Николаева И.С., Гюльазизова К.С, Морозова Н.В., Кабанкин А.С., Пынько Н.Э., Радкевич А.Д., Заховаева Е. Н., Сухинина Г.П., Кабаков Е.А. Роль фенотипа NAT2 в предрасположенности к раку печени.
  21. Evans W.E. Pharmacogenomics: marshalling the human genome to individualise drug therapy // Gut. 2003 May. 52 Suppl 2. ii10-8. Review.
  22. Hein D.W., McQueen C.A., Grant D.M., Goodfellow G.H., Kadlubar F.F., Weber W.W. Pharmacogenetics of the arylamine N-acetyltransferases: a symposium in honor of Wendell W. Weber. // Drug Metab Dispos. 2000 Dec. V. 28(12). P. 1425-32.
  23. Fawcett I.W., Gammon P.T. Determination of the acetylator phenotype in a Northern Nigerian population // Tubercle. 1975 Sep. V. 56(3). P. 199-201.
  24. Hildebrand M., Seifert W.Determination of acetylator phenotype in Caucasians with caffeine // Eur. J. Clin. Pharmacol. 1989. V. 37(5).P. 525-6.
  25. Piruzyan L.A., Radkevich L.A., Morozova N.V. The use of ethnic metabolic portraiture for the choice of individual pharmacotherapy strategy as exemplified by N-acetylation and chronic liver diseases // Dokl. Biol. Sci. 2003 Jan-Feb. V. 388. P.45-8.
  26. Armstrong A.R., Peart H.E. A comparison between the behavior of Eskimos and non-Eskimos to the administration of isoniazid // Am. Rev. Respir. Dis. 1960 Apr. V. 81. P. 588-94.
  27. Kontani K, Kawakami M, Nakajima T, Katsuyama T. Tobacco use and occupational exposure to carcinogens, but not N-acetyltransferase 2 genotypes are major risk factors for bladder cancer in the Japanese // Urol. Res. 2001 Jun. V. 29(3). P. 199-204.
  28. ГюльазизоваКС.Сравнительноеизучениесмертностиотсуицидавразличныхэтническихпопуляциях / Автореф. дисс. насоисканиестепени канд. биолог. наук. 2005.
  29. Хелимский А.М. // В кн. «Эпифиз». М.: 1969.
  30. Кветная Т.В., Князькин И.В. // В Кн. Мелатонин: роль и значение в возрастной патологии. С-Пб.: 2003. 94 с.
  31. Weissbluth L. and Weissbluth M. Синдром внезапной детской смерти: генетически детерминированное снижение развития фотонейроэндокринной (ФНЭ) системы. обобщение гипотез // J. Theor. Biol. 1994. V. 167. P. 13-25.
  32. Nielson D., Goldman D., Virkkunen M.et al. Suicidality and 5-hydroxyindo­lacetic acid concentration associated with tryptophan hydroxylase poly­morphism // Arch. Gen. Psychiatry. 1994. V. 51. P. 34-38.
  33. Mann J.J., Malone K.M., Nielsen D. et al. Possible association of a polymorphism of a tryptophan hydroxylase gene with suicidal behavior in depressed patients // Am. J. Psychiatry. 1997. V. 154. P. 1452-1453.
  34. Zalsman G, Frisch A., Apter A., Weizman A. Genetics of suicidal behavior: candidate association genetic approach. // Isr. J. Psychatry Realt. Sci. 2002. V.39 (4). P. 252-261.
  35. Du L., Faludi G., Palkovits M. et al.Frequency of long allele in serotonin transporter gene is increased in depressed suicide victims // Biol Psychiatry. 1999. V. 46(2). P. 196-201.
  36. Arango V., Huang Y., Underwood M.D. et al. Genetics of the serotoninergic system in suicidal behavior // J. Psychiatr. Res. 2002. V.37 (5). P. 375-386.
  37. Stanley M., Virgilio J., Gershon S.Tritiated imipramine binding sites are decreased in the frontal cortex of suicides // Science. 1982. V. 216. P. 1337-1339.
  38. Stanley M., Mann J. J.Increased serotonin-2 binding sites in frontal cortex of suicide victims. // Lancet. 1983. V. 1. P. 214-216.
  39. Mann J. J. Neurobiology of suicidal behaviour // Nature Reviews Neuroscience. 2003. V. 4. № 10. Р. 819-828.
  40. Mann J. J. et al.Attempted suicide characteristics and cerebrospinal fluid amine metabolites in depressed inpatients // Neuropsychopharmacology. 1996. V. 15. P. 576-586.
  41. Murphy G., Wetzel R.Family history of suicidal behavior among suicide attempters. J. Nerv. Ment. Dis. 1982. V. 180. P. 86-90.
  42. Batchelor I., Napier M.Attempted suicide in the old age // British Medical J. 1953. V. 2. P. 1186-1190.
  43. Roy A., Rylander G. Sarchiapore M. Genetic studies of suicidal behavior // The Psychiatric Clinics of North America. 1997. V. 20. № 3. P.595-611.
  44. Roy A., Segal N., Centerwall D et al. Suicide in twins //Arch. Gen. Psychiatry. 1991. V. 48. P. 29-32.
  45. Statham D.J., Heath A.C., Madden P.A.F et al. Suicidal behavior: an epidemiological and genetic study // Psychological medicine. 1998. V. 28. P. 839-855.
  46. Brent D.A., Bridge J., Johnson B.A. et al. Suicidal behavior runs in families. A controlled study of adolescent suicide victims // Arch. Gen. Psychiatry. 1996. V.53. P.1145-1152.
  47. Гайсина Д. А., Халилова З. Л., Хуснутдинова Э.К. Генетические факторы риска суицидального поведения // Журнал невроло­гии и психиатрии им. С.С. Корсакова. 2008. Т.108 (1). С. 87-91.
  48. http://www.who.int/.
  49. Павлушков И.В., Розовский Л.В., Капульцевич А.Е. Основы высшей математики и математической статистики: Учебник для медицинских и фармацевтических вузов Изд. 2-е, испр. М: ГЭОТАР МЕД. 2004.
  50. Герасимов А.Н.Медицинская ста­тистика: Учебное пособие М.: ООО «Медицинское информационное агентство». 2007. 480 с.
  51. В кн: Проблема расы в Российской физической антропологии. М. 2002. 96 с.