S.V. Sdobnikova, O.D. Gupalo, N.Y. Dorokhina, N.V. Krivosheeva, V.V. Sosnovskiy, A.L. Sidamonidze

In recent years a great attention in pathogenesis of diabetic retinopathy is given to disturbances of microcirculation. Hyperglycemia is the main damaging factor which initiates biochemical, hemodynamic and structural changes in vessels and organs of diabetic individuals. The aim of this study was to examine blood flow velocity and vascular resistance in the ophthalmic artery and central retinal artery in typies 1-2 diabetic patients. Sixty patients with type 2 and fifty one patients with type 1 diabetes mellitus were included. Blood flow parameters were measured by color Doppler imaging. All patients were divided into two groups: individuals with non-proliferative diabetic retinopathy and with no retinopathy. Each patient was examined in normoglycemia and hyperglycemia condition. As a result increase of such blood flow parameters as peak systolic velocity (PSV), end diastolic velocity (EDV) and flow volume as well as reduction of resistant index (RI) in patients with diabetic retinopathy durind hyperglycemia was revealed. Though in 12% of patients with no retinopathy during high blood glucose level increased ocular hemodynamics was also found. According to our opinion research of ocular blood flow in diabetic patients in different glycemia conditions is an important prognostic criterion of possible complications development.