E.S. Shamsutdinova1, M.V. Lomova2, R.A. Anisimov3

1 Kotel’nikov Institute of Radioengineering and Electronics of RAS (Moscow, Russia)

2,3 Chernyshevsky Saratov State University (Saratov, Russia))

Problem formulating. To increase the sorption capacity of calcium carbonate microparticles used as core for the development of targeted drug delivery, EDTA chelation of calcium ions was used to form a developed active surface of the particles. Goal. Is in modification of the surface of micron and submicron calcium carbonate vaterite particles using EDTA chelation of calcium ions and studying the effect of particle processing on their sorption capacity.

Result. It was shown using scanning electron microscopy that EDTA treatment of the CaCO3 surface leads to an increase on the surface roughness of the particles, as well as an increase on their sorption capacity according to spectrophotometric data. Practical meaning. Use of adsorption to encapsulate the active substance inside the carriers. It is shown that an increase in the sorption capacity of particles leads to an increase in the amount of a substance inside its volume.

Shamsutdinova E.S., Lomova M.V., Anisimov R.A. Controlling the adsorption of mineral porous particles by chelation. Nonlinear World. 2021. V. 19. № 2. 2021. P. 57−61. DOI: https://doi.org/10.18127/j20700970-202102-13 (In Russian)

1. Gusliakova O., Atochina-Vasserman E., Sindeeva O., Sindeev S., et al. Use of submicron vaterite particles serves as an effective delivery vehicle to the respiratory portion of the lung Frontiers in Pharmacology. 2018. № 9.
2. Petrov A.I., Volodkin D.V., Sukhorukov G.B. Calcium Carbonate Coprecipitation: A Tool for Protein Encapsulation. Biotechnology progress. 2008. V. 21. № 3.
3. Demina P.A., Degtjareva E.V., Kuz'micheva G.M., Bukreeva T.V. Polijelektrolitnye mikrokapsuly, modificirovannye nanorazmernym dioksidom titana, dlja adresnoj dostavki lekarstvennyh sredstv Vestnik MITHT im. M.V. Lomonosova. 2014. T. 9. № 4.  S. 76−79 (In Russian).
4. Chul Am Kim, Meyoung Ju Joung, Seong Deok Ahn, Gi Heon Kim, et al. Microcapsules as an electronic ink to fabricate color electrophoretic displays. Synthetic Metals. 2005. V. 151. Is. 3. P. 181−185.
5. Lili Wang, Joshua A. Jackman, Ee-Lin Tan, Jae Hyeon Park, et al. High-performance, flexible electronic skin sensor incorporating natural microcapsule actuators. Nano Energy. 2017. V. 36. P. 38−45.
6. German S.V., Novoselova M.V., Bratashov D.N., Demina P.A., et al. High-efficiency freezing-induced loading of inorganic nanoparticles and proteins into micron- and submicron-sized porous particles. Scientific reports. 2018. № 8. Р. 17763.
7. Kozlova, A.A., German S.V., Atkin V.S., Zyev V.V., Astle M.A., Bratashov D.N., Svenskaya Y.I., Gorin D.A. Magnetic Composite Submicron Carriers with Structure-Dependent MRI Contrast. Inorganics 2020. V. 8. № 2. Р. 11.