A.Е. Talipova – Post-graduate Student, Department of Anthropology, 

Faculty of Biology, Lomonosov Moscow State University 

E-mail: adelkamj@mail.ru 

N.A. Ryabchikova – Dr.Sc. (Biol.), Senior Research Scientist, 

Department of The Higher nervous activity, Faculty of Biology, Lomonosov Moscow State University; Skolkovo Institute of Science and Technology 

E-mail: nat@guesstest.ru 

V.А. Spitsyn – Dr.Sc. (Biol.), Professor, 

Research Centre for Medical Genetics (Moscow) 

E-mail: ecolab@med-gen.ru

Problem statement: In this work, we studied phenomenon of anxiety on the basis of the generally accepted in the psychodiagnosis modified eight-color Lusher test, the polymorphism of the gene for the angiotensin-converting enzyme (ACE), and the structure of their relationships among students of Moscow State University. The association of the I-allele of the ACE gene with an increase in the level of anxiety in young men has been revealed. We also found that the I-allele is associated with an increase in TD - the total deviation from the autogenic norm (the increase of the neuropsychic stress) and the decrease in the value of the vegetative coefficient (CV), i.e. the I-allele is associated with the predominance of excitation of the parasympathetic nervous system (NS).

Purpose: to investigate the relationship of the structure of mental stress variability, reflecting physiological dominate the sympathetic or parasympathetic division of the vegetative nervous system with gene polymorphism Angiotensin-converting enzyme (ACE), conduct quantitative analysis of this taking into account gender differences and build a neurocomputing model. 

Results: The association of the I-allele of the ACE gene with an increase in the level of anxiety in young men has been revealed. We also found that the I-allele is associated with an increase in TD - the total deviation from the autogenic norm (the increase of the neuropsychic stress) and the decrease in the value of the vegetative coefficient (CV), i.e. the I-allele is associated with the predominance of excitation of the parasympathetic nervous system (NS). Among boys there are more subjects with a high level of anxiety than among girls, despite the fact that boys have an optimal level of efficiency. Ergotropic dominance of sympathetic vegetative NA prevails in young men, and trophotropic dominance of parasympathetic NS dominates in girls. In young men, the I-allele of the ACE gene is associated with an increase in the level of anxiety, an increase in neuropsychic tension and the dominance of the parasympathetic NA. To assess the availability and quality of communication between the test results obtained by the methods of the Luscher, and ACE gene polymorphism correlation analysis was conducted using nonparametric methods. For convenience, have been assigned to various genotypes the following values: DD-1, ID-2, II-3, allowing mathematically correctly compare results. The analysis showed that boys between the level of anxiety and ACE gene polymorphism there is reliable positive correlation (gamma = 0.358, p = 0.0013), i.e. I-ACE Gene allele is associated with increasing levels of anxiety. We also identified the Association of alleles I with increase CO (the intensification of mental stress) (gamma = 0.364, r = 0.0011) and decreasing the value of kV-vegetation factor (gamma = 0.285, p = 0.0116), i.e. I-allele is associated with a predominance of excitation of the parasympathetic nervous system (trophotropic domination), and D-allele with the dominance of Ergotropic tonus (predominance of ssympathetic NS arousal). Under the predominance of the parasympathetic excitation NS means fatigue, the desire for peace, but under the predominance of arousal of the sympathetic NS overexcited.

Practical relevance: identifying the problem, setting the problem and developing practical recommendations for software manufactures connection gene polymorphisms RAAS with various mental processes as in the central nervous system, there are numerous receptors to proteins RAAS and very likely and their considerable influence on its activities. The obtained results can be used also in Bioengineering and for designing "smart" brain-computer systems.

Talipova A.E., Ryabchikova N.A., Spitsyn V.A. Neurocomputer analysis of insertion/deletion polymorphism in the gene for angiotensin converting enzyme and anxiety in students. Neurocomputers. 2020. V. 22. № 1. P. 31–38. DOI: 10.18127/j19998554-202001-03.

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