N.A. Ryabchikova – Dr.Sc. (Biol.), Senior Research Scientist, Department of the Higher Nervous Activity,  Faculty of Biology, Lomonosov Moscow State University 

E-mail: nat@guesstest.ru

E.V. Damyanovich – Ph.D. (Med.), Senior Research Scientist, Laboratory of Neurocybernetic,  Scientific center of neurology (Moscow)

E-mail: damjanov@iitp.ru

L.A. Chigaleychik – Ph.D. (Med.), Senior Research Scientist, Laboratory of Neurocybernetic,  Scientific center of neurology (Moscow)

E-mail: shkolapd@rambler.ru 

B.Kh. Baziyan – Sc.D. (Biol.), Head of the Laboratory Neurocybernetic,  Scientific center of neurology (Moscow)

E-mail: baz123@yandex.ru

Parkinson’s disease (PD) is a slowly grow progressively neurodegenerative disease of the nervous system. It manifests tremor, hypokinesias, muscular rigidity, postural instability. In most cases, patients with PD have violations of cognitive functions. The process of prognosis the appearance of the events is one of the cognitive brain functions underlying of the human intellectual activity. Numerous studies have shown that cognitive processes (attention, memory, thinking) accompanied by saccadic eye movements. Moreover, the cognitive processes are often complicated without those movements. Functional and anatomical overlapping of brain structures (frontal and parietal cortex areas, basal ganglia) provides, on the one hand, the process of planning, programming and decision-making, on the other – the control of saccades generation. 

1. Aarsland D., Andersen K., Larsen J.P. Prevalence and characteristics of dementia in Parkinson’s disease: an 8-year prospective study // Arch. Neurol. 2003. V. 60. P. 387–392. 
2. Brown R.G., Marsden C.D. How common is dementia in Parkinson’s disease? Lancet, 1984. V.2. P. 1262–1265.
3. Cummings J.L. Intellectual impairments in Parkinson’s disease: clinical, pathological and biochemical correlates // J. Ger. Psych. Neurol. 1988. № 1. P. 24–36.
4. Bazyian B.Kh., Chigaleichik L.A., Dmitriev I.E. Possible mechanisms of disorders of saccadic eye movements in patients with Parkinson's disease // Bull. Exp. Biol. Med. V. 125. № 3. P. 254–259. 
5. Baziyan B.Kh., Chigaleichik L.A., Teslenko E.L., Damjanovich E.V., Shvetsov A.Yu., Ivanova E.A., Ivanova-Smolenskaya I.A., Illariushkin S.N. Disorders of arbitrary hand-eye movements of patients with early stages of Parkinson's disease // Neurology and Neurosurgery in Belarus. 2011. V. 10. № 2. P. 65–81.
6. Ryabchikova N.A. Baziyan B.Kh., Polyansky V.B., Pletnev O.A. the Role of saccadic eye movements in cognitive processes // Bull. Exp. Biol. and Honey. M.: 2009. V. 147. № 1. P. 11–14.
7. Moskalenko Y.E., Ryabchikova N.A., Halvorson W., Vardy T.C. Changes of Circulatory – Metabolic Indices and Skull Biomechanics with Brain Activity During Aging // Journal of Integrative Neuroscience. Transdisciplinary Journal, Imperial College Press. 2011. V. 10. № 2. P. 131–160.