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Journal Neurocomputers №8 for 2014 г.
Article in number:
Cytogenetic investigation of lymphocytes of peripherial blood of workers of metal processing
Keywords: cytogenetic studies metalworking mutagens genotoxicity chromosomes
Authors:
N. N. Omelchuk - Ph.D. (Biol.), Professor, Head of department, Department of clinical laboratory diagnostics, Medic's Retraining Faculty, Russian University of Peoples Friendship (Moscow). E-mail: kkld-fpkmr@mail.ru
R. Ya. Tataritntseva - Dr.Sc. (Med.), Professor, Head of department, Department of clinical physiology and non-medicamental methods of therapy, Medic's Retraining Faculty, Russian University of Peoples Friendship (Moscow). E-mail: kkf-fpkmr@mail.ru
D. S. Stasytyte-Buneviciene - Ph.D. (Med.), Lecturer of department, Department of clinical physiology and non-medicamental methods of therapy, Medic's Retraining Faculty, Russian University of Peoples Friendship (Moscow). E-mail: kkf-fpkmr@mail.ru
Abstract:
In literature issues information about mutagenic and genotoxic activity of chemical substances used in technology of metal processing is announced. Present study aimed to investigate cytogenetic indices of lymphocytes of peripherial blood of people working under impact of harmful factors of metal processing for a long-term period. 31 workers from 2 shops from enterprise of heavy industry aged 35-54 years took part in the investigation. Control group was formed of 90 persons of the same age without contact with genotoxic industrial agents. Chromosoma were studied, detecting aberrant metaphases and chromosomal aberrations in lymphocytes of peripherial blood. Chromosomal aberrations in lymphocytes of workers from the 1-st shop were found more often, by 31.8% if comparing with the same ones of control group (p < 0.05). During cytogenetic investigation, alterations of chromosomas in lymphocytes of peripherial blood of people working under impact of harmful chemical agents of metal processing were detected. Genotoxicity of industrial agents manifested as chromatidial and chromosomal aberrations and correlated to level of industrial contamination. No significant differences of injuries according to sex and smoking were found.
Pages: 47-50
References

  1. Oxrana truda pri ispol'zovanii ximicheskix veshhestv na rabochix mestax / Gruppa texnicheskoj podderzhki po voprosam dostojnogo truda i Byuro MOT dlya stran Vostochnoj Evropy' i Central'noj Azii. M.: MOT. 2014.
  2. Profilaktika professional'ny'x zabolevanij. Vsemirny'j den' oxrany' truda 28 aprelya 2013 g. M.: MOT. 2013.
  3. Razdorozhny'j A.A. Oxrana truda i proizvodstvennaya bezopasnost'. M.: E'kzamen. 2006. 510 s.
  4. Rossijskaya e'ncziklopediya po oxrane truda: V 3 t. 2-e izd., pererab. i dop. M.: Izd-vo NC E'NAS. 2007.
  5. Heloma A., Kahkonen E., Kaleva S., et al. Smoking and exposure to tobacco smoke at medium-sized and large-scale workplaces // American Journal of Industrial Medicine. 2000. V. 37. № 2. P. 214-220.
  6. Control of hereditary diseases: Rep. of a WHO Sci. group. Geneva, WHO. 1996.
  7. The World Health Report 2002. Reducing risks, promoting healthy life. WHO, Geneva. 2002. P. 7 - 26.
  8. Princzipy', pravila i proczedury', ispol'zuemy'e MAIR pri oczenke riska kanczerogennosti dlya cheloveka razlichny'x faktorov / Per. s angl. prof. M.A. Zabezhinskogo. 2006.
  9. Xvostunov I.K., Kursova L.V., Shepel' N.N. i dr. Oczenka czelesoobraznosti primeneniya biologicheskoj dozimetrii na osnove analiza xromosomny'x aberraczij v limfoczitax krovi bol'ny'x rakom legkogo pri terapevticheskom frakczionirovannom y-obluchenii / Radiaczionnaya biologiya. Radioe'kologiya. 2012. № 5. C. 467-480.
  10. Gajner T.A. Optimizacziya diagnostiki xromosomny'x anomalij cheloveka: Dis. k.b.n. Novosibirsk. 2004. 127 c.
  11. Minina V.I. Xromosomny'e aberraczii u zhitelej Kemerovskoj oblasti, prozhivayushhix na territoriyax s razlichny'm urovnem zagryazneniya atmosfernogo vozduxa // Izv. Samarskogo nauch. czentra RAN. 2012. T. 14. № 5(2).
  12. Minina V.I., Druzhinin V.G., Glushkov A.N. i dr. Kolichestvenny'e xarakteristiki chastoty' xromosomny'x aberraczij u zhitelej rajonov s razlichny'm urovnem onkologicheskoj zabolevaemosti // Genetika. 2009. T. 45. № 2. C. 239-246.