E. P. Murtazina - Ph.D. (Med.), Associate Professor, P.K. Anokhin Institute of normal physiology (Moscow). E-mail: e.murtazina@nphys.ru
B. V. Zhuravlev - Dr.Sc. (Med.), Professor, Head of Laboratory, P.K. Anokhin Institute of normal physiology (Moscow). E-mail: b.zhuravlerb@nphys.ru

Analysis of the processes of studying instructions follow-up in terms is relevant for research system processes of learning and memory, and is also important for such as psychophysiology of focused attention, understanding the meaning of the information provided and the formation of social motivation in human activities. Based on the theory of functional systems academician of PK Anohin, we can assume that the study of instructions included in one of the leading stages of functional systems for goal directional behavioral activity - afferent synthesis. At this stage, on the basis of social motivation, information about the situational and triggers signals, the memories of possible means for achieving results formed the follow-up programs and acceptor of the results. In connection with the above, the purpose of the investigation to conduct a system analysis of neurophysiological indicators goal directional attention during the human reading the instruction to perform follow-up test. Surveys was carried out on 22 volunteers (11 males and 11 females) aged 18 to 22 years old, relatively healthy, who gave informed consent to participate in the study. The examination included registrations of the ECG and EEG 8 cortical areas of the brain for 3 minutes in a state of operational rest before testing, when reading the instructions on the computer screen (the duration of her reading was not limited), as well as the subsequent testing implementation of previously developed visual-motor test «Shooter». The study revealed that the process of studying the instruction causes emotional stress, which manifests itself in an increase in heart rate, reducing variability and the increase in low frequency spectral power, as sympathetic components of heart rate regulation. It was shown that increase in spectral power of theta or beta EEG rhythms taken place in frontal and visual areas of the cerebral cortex of subjects, respectively. It is found that the changes of coherent in their relations with other regions of the cortex were opposed: the coherence from the visual areas intensified, and from the frontal - weakened. These characteristic neurophysiological changes correlated with indicators of follow-up visual-motor test execution: learning rate, efficiency and tactics, resistance to mismatching after error.