M.A. Yarmolenko - Ph.D. (Eng.), Associate Professor, F. Scorina Gomel State University (Gomel). Е-mail: simmak79@mail.ru

The article determines the kinetic, physical and chemical laws of deposition of thin composite coatings based on polyethylene glycol and silver nanoparticles from the active gas phase formed by electron-beam dispersion of the polymer and silver salt, as well as the changes in structure and morphology under their heat treatment. The paper shows that during the heat treatment of coatings baed on AgNO3 salt decomposition occurs with the formation of silver nanoparticles. The decomposition of the salt to a metal occurs sequentially through the stage of formation of silver oxide. The polyethylene glycol matrix prevents the coalescence of the nanoparticles formed and thermally stabilizes the salt. The formation of a considerable amount of silver oxide in the composite layer during the heat treatment is a consequence of the salt thermal stabilization. Annealing of the polyethylene glycol layer in the presence of silver nitrate is not accompanied by an intense thermal oxidative destruction of the organic material. Composite silver-containing coatings based on PEG may be used as prolonged antibacterial layers on implant surfaces.

 

1. Luchnikov P.A., Rogachev A.A., Luchnikov A.P. Nanostrukturnye i morfologicheskie svojjstva vakuumnykh ftorpolimernykh plenok na kremnii // Nano- i mikrosistemnaja tekhnika. 2007. № 10. S. 6-11.
2. Ivanov V.I., Luchnikov P.A., Sigov A.S. Ionnye tekhnologii v proizvodstve izdelijj ehlektronnojj tekhniki: Ucheb. posobie / Pod red. A.S. Sigova. M.: EHnergoatomizdat. 2010. 206 s.
3. JArmolenko M.A., Rogachev A.A., Rogachev A.V., Luchnikov P.A., Gorbachev D.L. Tonkoplenochnye kompozity na osnove poliehtilena s vkljucheniem nanochastic medi // Izvestija vysshikh uchebnykh zavedenijj. Ser. Fizika. 2013. T. 56. № 1-2. S. 147-150.
4. JArmolenko M.A., Rogachev A.A., Rogachev A.V., Tapalskijj D.V., Gorbachev D.L., Luchnikov P.A. Plazmokhimicheskijj sintez nanokompozicionnykh biosovmestimykh pokrytijj, obladajushhikh antibakterialnym prolongirovannym dejjstviem // Naukoemkie tekhnologii. 2011. T. 12. № 5. S. 26-34.
5. JArmolenko M.A., Rogachev A.A., Luchnikov P.A., Rogachev A.V. Struktura vakuumnykh kompozicionnykh pokrytijj polimer - serebro, osazhdennykh pri ehlektronno-luchevom raspylenii komponentov // Izvestija vysshikh uchebnykh zavedenijj. Ser. Fizika. 2013. T. 56. № 1-2. S. 276-279.
6. Luchnikov P.A., Rogachev A.A., JArmolenko M.A., Luchnikov A.P. Segregacija nanochastic serebra v sloistykh metall-polimernykh geterostrukturakh pri termicheskojj obrabotke // EHlektronnaja tekhnika. Ser. 2: Poluprovodnikovye pribory. 2014. № 2 (233). S. 63-72.
7. Rogachev A.A., Yarmolenko M.A., Jiang Xiaohong, Rogachev A.V., Shen Ruiqi, Yingjie Zhou. Heat treatment impact on molecular structure of polymer-based silver containing coatings deposited from the active gas phase // Progress in Organic Coatings. 2015. V. 81. P. 80-86.
8. Borse V., Pawar V., Shetty G., et al. Nanobiotechnology perspectives on prevention and treatment of orthopaedic implant associated infection // Curr Drug Deliv. 2016. V. 13 № 2. P. 175-85.
9. Simchi A., Tamjid E., Pishbin F., Boccaccini A.R. Recent progress in inorganic and composite coatings with bactericidal capability for orthopedic applications // Nanomedicine: Nanotechnology, Biology, and Medicine. 2011. № 7. P. 22-39.
10. Donelli G. (ed.) Biofi lm-based Healthcare-associated Infections: Volume II, Advances in Experimental Medicine and Biology 831, DOI 10.1007/978-3-319-09782-4_7, Springer International Publishing Switzerland 2015.
11. Siedenbiedel F., Tiller J.C. Antimicrobial Polymers in Solution and on Surfaces: Overview and Functional Principles // Polymers. 2012. V. 4. P. 46-71.
12. Ivanova E.P., Crawford R.J. (eds.) Antibacterial Surfaces, DOI 10.1007/978-3-319-18594-1_5, Springer International Publishing Switzerland 2015.
13. Ragaseema V.M., Unnikrishnan S., Krishnan V.K., Krishnan L.K. The antithrombotic and antimicrobial properties of PEG-protected silver nanoparticle coated surfaces // Biomaterials. 2012. V. 33. № 11. P. 3083-3092.
14. Bastos V., F. de Oliveira J.M.P., Brown D., Jonhston H., Malheiro E., Daniel-da-Silva A.L., Duarte I.F., Santos C., Oliveira H. The influence of Citrate or PEG coating on silver nanoparticle toxicity to a human keratinocyte cell line // Toxicology Letters. 2016. V. 249. P. 29 ? 41.
15. Toxic effect of high concentration of sonochemically synthesized polyvinylpyrrolidone coated silver nanoparticles on Citrobacter sp. A1 and Enterococcus sp. C1, Journal of Microbiology, Immunology and Infection (2015) // http://dx.doi.org/10.1016/j.jmii. 2015.08.004.
16. Yang C., Yang H., Wu J., Meng Z., Xing R., Tian A., Tian X., Guo L., Zhang Y., Nie G., Li Z. No overt structural or functional changes associated with PEG-coated gold nanoparticles accumulation with acute exposure in the mouse heart // Toxicology Letters. 2013. V. 222. № 2. P. 197-203.
17. D-souza A.A., Shegokar R. (2016): Polyethylene glycol (PEG): A versatile polymer for pharmaceutical applications, Expert Opinion on Drug Delivery, DOI: 10.1080/17425247.2016.1182485.
18. Mirzaeian M., Ogwu A.A, Jirandehi H.F., Aidarova S., Ospanova Z., Tsendzughul N. Surface Characteristics of Silver Oxide Thin Film Electrodes for Supercapacitor Applications // Colloids and Surfaces A: Physicochemical and Engineering Aspects http: // dx.doi.org/10.1016/j.colsurfa.2016.04.026.
19. Liu Zhubo, Rogachev A.A., Zhou Bing, Yarmolenko M.A., Rogachev A.V., Gorbachev D.L. Xiaohong Jiang Electron-Beam Deposition of Polyethylene Composite Coatings at Various Initiators and Inhibitors // Polymer Engineering & Science. 2013. V. 52. № 10. P. 2134-2139.
20. Bellamy L.J. The Infra-red Spectra of Complex Molecules. Molecular spectra,Methuen, Methuen & Co. Ltd., London. 1954. R. 323.
21. Ma Jizhen, Zhang Jintao, Xiong Zhigang, Yong Yu, Zhao X.S. Preparation, characterization and antibacterial properties of silver-modified graphene oxide // J. Mater. Chem. 2011. V. 21. № 10. P. 3350-3352.
22. Hoflund G.B., Weaver J.F., William S. Epling Ag2O XPS Spectra // Surface Science Spectra. 1994. V. 3. № 2. P. 157-162.
23. Dafeng Zhang, XipengPu, Huaiyong Li, Young Moon Yu, Jae Jeong Shim, PeiqingCai, Sun Il Kim, Hyo Jin Seo. Microwave-assisted combustion synthesis of Ag/ZnOnanocomposites and their photocatalytic activities under ultraviolet and visible-light irradiation // Materials Research Bulletin. 2014. V. 61. P. 321-325.
24. Ferraria A.M., Carapeto A.P., Botelho do Rego A.M. X-ray photoelectron spectroscopy: Silver salts revisited // Vacuum. 2012. V. 86. № 12. P. 1988-1991.
25. Sun J., Rogachev A.V., Yarmolenko M.A., Rogachev A.A., Jiang X., Tapal\'skii D.V., Gorbachev D.L., Bespal\'ko A.A. Nanocomposite coatings based on copper and the products of polyethylene destruction, features of their formation, structure and antibacterial properties // RSC Adv. 2016. V. 6. № 35. P. 29220-29228.