V.V. Anshakova - Ph.D.(Pedag.), Associate Professor, North-Eastern Federal University (Yakutsk). E-mail: anshakоva_v@mail.ru

Searching the ways of increasing the intensity of existing pharmaceuticals and biologics is a actual task because of long-term and high cost (investment) of new drugs and biologics development process. One of the most promising attempt is creation of mechanochemical complexes based on polymer matrix of natural poly- and oligosaccharides prolonging the activity of API, increasing of its biological (incl. therapeutic) effect in a few times, while reducing the toxicity is one of the most promising area. Using this solid-state technology of treatment of substances based on physical and chemical effects that are common for Applied Mechanochemistry - from activation of solids due to disordering and defect formation till solid-phase chemical reactions directly in the processing. Given paper describes toxicological tests data - determination of product safety and the potential toxic effects of biological product "Yagel Detox". During clinical research phase of animals lifetime were registered signs as possible toxicity, body weight, food consumption. According to the results of toxicological studies of animals intoxication signs are not marked, there were no instances of fatal outcomes. Haven't been identified statistically significant differences between control animals treated with saline solution and animals that received the test drugs. In the control group which received saline solution weren't registered differences between individuals of both sexes in the parameters body weight gain. After the introduction in mice of study medication wasn't observed pronounced changes in biochemical parameters of blood serum, which could indicate a toxic changes in internal organs.