350 rub
Journal №9 for 2014 г.
Article in number:
Synthesis and antihypoxic activityof tricyclic compounds cotaining 5,6,7,8-tetra-hydroquiniline moiety
Keywords: tricyclic compounds 5 6 7 8-tetrahydroquinoline moiety antihypoxic activity normobaric hypoxia hemic hypoxia mexidol
Authors:
S.S. Zykova - Ph.D. (Pharm), Associate Professor of Chair Zootechnology, Federal Penitentiary Service Institute of Russia (Perm)
T.F. Odegova - Dr.Sc. (Pharm), Professor, Head of the of Chair of Microbiology, Perm Pharmaceutical Academy (Perm). E-mail: veto2007@yandex.ru
D.A. Rudenko - Ph.D. (Chem), Assistant of Chair Organic Chemistry, Perm National Reseaching University (Perm). E-mail: daryaru@yandex.ru
T.V. Shavrina - Ph.D. (Chem), Assistant of Chair Organic Chemistry, Perm National Reseaching University (Perm)
S.N. Shurov - Dr. Sc. (Chem), Professor, Head of the of Chair Organic Chemistry, Perm national Research University (Perm). E-mail: seshurov@yandex.ru
Abstract:
The purpose of research - find connections among tricyclic compounds, containing 5,6,7,8-tetrahydroquinoline moiety with antihypoxic activity. Antihypoxic activity studied fourtricyclic compounds, containing 5,6,7,8-tetrahydroquinoline moiety. On two models of hypoxia - hypercapnia with normobaric and hemic - studied antihypoxic synthesized compounds. As a comparison drug used modern antioxidant and antihypoxant, сontains2-ethyl-6-methyl-3-hydroxypyridine succinate. Assessment antihypoxic actions performed over time to increase life expectancy of mice under conditions of acute hypoxia. Synthesized in the presence of tricyclic compounds significantly increases the lifetime of the mice models hemic and normobaric hypoxia, and this figure exceeds the reference drug. The model hemic hypoxia compound having a methyl radical increased the time span of mice by 40 %. Antigipoksical research activity on the model normobaric hypoxia showed that the most effective compound was IIId, which increased the lifespan of mice by 47.1 %.The synthesized compounds showed moderate and high antihypoxic activity.
Pages: 14-17
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