D.V. Rogozhin - Ph.D.(Med.), Head of Department Pathology, Russian Children-s Clinical Hospital, Moscow, Russia. E-mail: Pathol.777@mail.ru
I.V. Boulytcheva - Dr.Sc.(Med.), Head of Department Pathology, Moscow City Clinical Hospital №45
A.G. Talalaev - Dr.Sc.(Med.), Professor, Pathologist, Russian Children-s Clinical Hospital, Moscow, Russia
D.M. Konovalov - Ph.D.(Med.), Pathologist, Russian Children-s Clinical Hospital, Moscow, Russia
A.P. Ektova - Pathologist, Department Pathology, Russian Children-s Clinical Hospital, Moscow, Russia
V.Yu. Roshin - Pathologist, Russian Children-s Clinical Hospital, Moscow, Russia

Analised of bone pathology in children and adolescence is the morphologic expression of a broad spectrum of diseases, including those caused by genetic (sporadic and inherited), malformative, inflammatory, metabolic, circulatory, traumatic and neoplastic conditions. The main focus of this paper is the realistic data about the distribution of benign, malignant and genetic disorders based on analyses of all bone lesions registered from 2009 till 2014 in Children-s Hospital in Moscow. The topic is one of the most difficult in surgical pathology because bone tumors are rare. It is very difficult to obtain professional experience with all histological variants and tumor mimics in bone pathology. The practical modern approach for making a correct diagnosis require careful integration of radiologic imaging studies, clinical and morphologic data with broad addition of modern genetic analyses.