350 rub
Journal №8 for 2014 г.
Article in number:
Experimental and clinical studies of RANK/RANKL/OPG system in metastatic bone tumors
Keywords: RANK RANKL OPG metastases bones
Authors:
N.E. Kushlinskii - Dr.Sc. (Med.), Professor, Russian Cancer Research Center of N.N. Blokhin Russian Academy of Medical Sciences (Moscow). E-mail: biochimia@mtu-net.ru
A.A. Zuev - Post-graduate Student, Moscow State University of Medicine and Dentistry a.n. A.I. Evdokimov
Yu.S. Timofeev - Physician Clinical Laboratory Diagnosis, Russian Cancer Research Center of N.N. Blokhin Russian Academy of Medical Sciences (Moscow)
Abstract:
The system of receptor activator of nuclear factor kappa-B - is an important element of bone homeostasis, playing the key role in the process of bone remodeling. The systems consists of the receptor (RANK), its ligand (RANKL), and the osteoprotegerin (OPG), the free receptor of RANKL, which prevents its binding on the surface of osteoclasts. Disorders in the functioning of this system may lead to development of some diseases, like osteoporosis, Paget's disease, Camurati-Engelmann disease, bone erosions. Disbalance of bone homeostasis, associated with malfunctioning of RANK/RANKL/OG system underlies the oncological processes such as the destruction of bone, metastasis development, tumor progression. Pathological activity of system was described in such conditions, as breast cancer, prostate cancer, multiple myeloma, squamous cell carcinoma, Hodgkin's disease, and also metastasis in bones from lung cancer and other malignant diseases. In the literature, there is evidence of involvement of RANK/RANKL/OPG system in the pathogenesis of bone tumors (giant cell tumor of bone, chondroblastoma). Experimental data shows that RANKL inhibitors can play a role in reducing tumor-induced lesions of bone in multiple myeloma, breast cancer, prostate cancer and lung cancer. Also this review presents data from clinical studies of the drug efficacy targeted on RANK/RANKL/OPG system.
Pages: 3-11
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