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Journal №5 for 2014 г.
Article in number:
Synthesis and hemorheological activity of 8-amino-substituted 1-ethyl-3-methyl-7-(1,1-dioxothietanyl-3)xanthines
Keywords: xanthines thietanes hemorheological activity
Authors:
Yu.V. Shabalina - Ph.D. (Parm.), Associate Professor, Bashkir State Medical University, Ufa, Bashkortostan. E-mail: fil-ko@mail.ru
F.A. Khaliullin - Ph.Sc. (Parm.), Professor, Bashkir State Medical University, Ufa, Bashkortostan. E-mail: khaliullin_ufa@yahoo.com
A.А. Spasov - Dr. Sc. (Med.), Professor, Volgograd State Medical University, Volgograd. E-mail: aspasov@mail.ru
L.V. Naumenko - Dr. Sc. (Med.), Volgograd State Medical University, Volgograd. E-mail: milanaumenko@mail.ru
V.A. Kuznetsova - Ph.D. (Med.), Volgograd State Medical University, Volgograd. E-mail: sysoeva_va@mail.ru
Abstract:
Pentoxifylline (1-(5-oxohexyl)-3-methylxanthine) is used to improve the microcirculation and blood rheology in violations of peripheral blood circulation. Analogs of pentoxifylline - 8-amino-substituted 1-alkyl-3-methyl-7-(thietanyl-3)xanthines showed antiaggregaition properties on erythrocytes. Hemorheological activity comparable to that of pentoxifylline, also showed 8-substituted 1-alkyl-3-methyl-7-(1-oxothietanyl-3)xanthines. 8-Bromo-1-ethyl-3-methyl-7-(1,1-dioxothietanyl-3)xanthine was synthesized by oxidation of 8-bromo-1-ethyl-3-methyl-7-(thietanyl-3)xanthine. A new 8-amino-substituted 1-ethyl-3-methyl-7-(1,1-dioxothietanyl-3)xanthines were obtained with 14-75% yields using 8-bromo-1-ethyl-3-methyl-7-(1,1-dioxothietanyl-3)xanthine and various reagents (piperidine, hexamethyleneimine, morpholine, monoethanolamine, and trisamine). The structure of the synthesized compounds was confirmed by IR, 1H NMR spectroscopy. The synthesized compounds exhibit hemorheological activity.
Pages: 20-23
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