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Journal №4 for 2014 г.
Article in number:
Synthesis, properties and biological activity ylidene derivatives of 2-oxoquinoline-4-carboxylic acid hydrazide
Keywords: 2-oxo-1 2-dihydroquinoline-4-carboxylic acid ethyl ester 2-oxo-1 2-dihydroquinoline-4-carboxylic acid hydrazide 2-oxo-1 2-dihyd¬roquinoline-4-carboxylic acid ylidene derivatives antiinflammatory analgetic antimicrobial activity
Authors:
A.N. Dubrovin - Post-graduate Student, Department, Biological Chemistry, Perm State Pharmaceutical Academy, Russia, Perm. E-mail: andovin@yandex.ru
A.I. Mikhalev - Dr. Sc. (Pharm.), Perm State Pharmaceutical Academy, Russia, Perm. E-mail: biolhim@pfa.ru
S.V. Ukhov - Ph. D. (Pharm.), Perm State Pharmaceutical Academy, Russia, Perm
T.M. Konshina - Ph. D. (Pharm.), Perm State Pharmaceutical Academy, Russia, Perm
V.V. Novikova - Ph. D. (Pharm.), Perm State Pharmaceutical Academy, Russia, Perm
R.R. Makhmudov - Ph. D. (Pharm.), Institute of Natural Sciences, Perm State National Research University, Russia, Perm
Abstract:
The synthesis of some previously unknown 2-oxo-1,2-dihydroquinoline-4-carboxylic acid ylidene hydrazide derivatives by heating of 2-oxo-1,2-dihydroquinoline-4-carboxylic acids with aldehydes or ketones in good yields is reported. The structures of synthesized compounds have been confirmed on the basic NMR H1 spectral data. Ethyl ester and 2-oxo-1,2-dihydroquinoline-4-carboxylic acid hydrazide have been screened on animals for their acute toxicity, antiinflammatory, analgesic and antimicrobial activity, as well 2-oxo-1,2-dihydroquinoline-4-carboxylic acid ylidene hydrazide derivatives as compared to the reference substances: diclofenac sodium, acetylsalicylic acid, metamizol sodium, dioxydinum. Synthesis technique 2-oxo-1,2-dihydroquinoline-4-carboxylic acid ylidene hydrazide derivatives can be used in preparative organic chemistry for synthesis of potentially biologically active quinoline-4-carboxylic acid derivatives.
Pages: 14-20
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