S.S. Zykova - Ph. D. (Pharm), Associate Professor of Chair Zootechnology,Тhe Federal State Educational Institution of Higher Education Federal Penitentiary Service Institute of Russia (Perm.). E-mail: zykova.sv@rambler.ru
T.F. Odegova - Dr. Sc. (Pharm), Professor, Head of the Department of Microbiology,the Federal State Educational Institution of Higher Education Perm Pharmaceutical Academy (Perm.). E-mail: veto2007@yandex.ru

In recent years, most studies proved that the majority of pathologic processes progress due to common toxic condition - oxidative stress. Its formation is initiated by free radicals (FR) ? extraordinary active chemicals with one valenсe electron. At the heart of FR formation mechanism are chain reactions, which were analyzed and described by the N.M.Emanuel [1]. Free radicals pool in the organism causes active forms of oxygen (AFO), which are formed moderately during normal vital activity of cell and proliferate in case of hypoxia or excessive mitochondria load. Compounds with different chemical structure and general functionality, called "antioxidants", are the natural "protection" against aggression of AFO []. In connection with the foregoing list of modern antioxidants is important. Source for a large number of biologically active heterocycles are the reaction of 1,3,4,6-tetracarbonyl systems with various nucleophilic agents. Reactions of 1, 3, 4, 6-tetrakarbonyl compounds with Schiff bases led to derivation of 6-aryl-substituted-4-benzoylacetyl-4-hydroxy-5, 6-dihydro-4H-1, 3-oxazines, which are quite promising to be studied as antioxidants and antimicrobial agents. Antioxidant activity was studied on the Esсherichia coli BW 25113 strain grown aerobically in M-9 minimal liquid medium with glucose. When constructing a model of oxidative stress with 3 mm hydrogen peroxide solution on cells of E. coli BW 25113 strain there was observed specific growth of cells per 1 hour with 6 substances of oxazine group. Earlier it was shown that pro-oxidant effect in a certain way protects E. coli cells from sizeable hydrogen peroxide concentration [5]. Antimicrobial activity of synthesized oxazines studied on three strains (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa). The most significant is bacteriostatic activity of the 6-аryl-4-benzoylacetyl-4-hydroxy-5,6-dihydro-2-p-methoxyphenyl-3-methylphenyl-4Н-1,3-оxazine.