V.V. Karabaeva - Research Scientist, Department of Experimental and Clinical Pharmacology, Medical Center,All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (VILAR), Moscow, Russia. E-mail: vera-karabaeva@rambler.ru

Тanacechol is the original domestic medicine, described in the foreign pharvacopeia, it is a purified extract, produced from flower of - Tanacetum vulgare L. family Asteraceae. The major components determining its biological activity, are flavonoids and phenol carbonic acids the content of which in substance exceeds moreases 50 % calculating on luteolin. There were carried out analysis of the experimental and clinical study. Тanacechol moreases formation and secretion of bile, promotes the change of its biochemical composition. It is shown that the tanacechol has spasmolytic effect on the gall bladder, biliary ducts and intestines, being practically non-toxic. Clynical tryals of tanacechol was carried out in 5 medical establishments on 261 patients aged 18-75 years ( male - 18,7 % and female - 81,3 %) with acute exacerbation of chronic cholecystitis, functional disorders of bile passages on the background of chronic diseases of digestive organs and physico-chemical stage of gallstone while disease, the duration of disease was 1-15 years. During the examination of the patients there were used ultrasound, cholecystography, multifractional duodenal intubation, clinical analysis of blood, investigated the serum hepatogram study, biochemical composition and reaction of bile. Тanacechol was presoribed on 1-2 tablets for 20-30 minutes before meals 3 times a day during 2-4 weeks, at the background. The result was assessed by the dynamics of the main clinical symptoms, of laboratory data and instrumental methods of examination. The best clinical effect (74,9 %) was achieved daring use of tanacechol. in a daily dose of 6 tablets (2 tablets 3 times a day). Тanacechol act positively on biochemical composition of bile: reduction of total cholesterol and cholic acid (54.7 %), the increase of the total amount of bile acids, the content of chenodesoxycholic acid, cholato-cholesterol ratio. Indicators of DFА-reaction bile reliably decreased. Side effects have not been identified. Тanacechol in the form of tablets (0,05 г) is allowed for medical use for adults as a choleretic and spazmolitic for chronic nonvascular cholecystitis, hypomotor dyskinesia biliary tract, as well as for patients with postcholecystectomic syndrome. Тanacechol can be used in a monotherapy and in combination with other drugs. Тanacechol is the active component of the new, modern, original highly effective medicines - bellacechol and sybectan, used for the treatment of different diseases of the hepatobiliary system.