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Journal №12 for 2014 г.
Article in number:
Study the possibility of using the fruits of ammi majus for getting medicinal substances fotosensibilisate and antifungal activity
Keywords: furocoumarins ammifurine anmarine Ammimajus
Authors:
P.V. Krutov - Junior Research Scientist, All-Russia Scientific Research Institute of Medicinal and Aromatic Plants, Moscow. E-mail: krutovpv@mail.ru
A.I. Gromacova - Dr.Sc. (Pharm.), All-Russia Scientific Research Institute of Medicinal and Aromatic Plants, Moscow. E-mail: a_gromakova@mail.ru
Abstract:
Currently for drug development along with synthetic compounds are biologically active substances from plants derived. Ammimajus L. is an annual herbaceous cultivated plant, the fruits of which are a raw material for producing drug «Ammifurin» and «Anmarin». The purpose of this study was to develop cost-effective schemes to generate furocoumarins from the fruits of Ammimajus, allowing you to get two of the drug substance in a single process. In the study, the optimal conditions for extraction and purification of ammifurine, hydrolysis, chromatography out and dehydration of anmarinewas carried. The complex technology of processing of the fruits of Ammimajus is possible to reduce the consumption of raw materials per unit of product in 2.4 times, ethyl - 3,5 times, labor costs 3.3 times, which led to a significant reduction in the cost of the two drug substances.
Pages: 21-24
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