350 rub
Journal №1 for 2014 г.
Article in number:
Pathogenetic relations between long chain fatty acids' metabolism and cytokine profile in the affected areas of skin in psoriasis
Keywords: psoriasis skin long chain fatty acids cytokines
Authors:
T.M. Karavaeva - Ph.D. (Med.), Department of Chemistry and Biochemistry, Chita State Medical Academy, Associate Professor of Department. E-mail: KaTany1@yandex.ru
B.S. Khyshiktuev - D.Sc. (Med.), Professor, Department of Chemistry and Biochemistry, Chita State Medical Academy. E-mail: bair-k@yandex.ru
E.V. Fal'co - Ph.D. (Med.), Associate Professor, Department of Dermatology and Venereology, Chita State Medical Academy. E-mail: Falko_elena@inbox.ru
P.P. Tereshkov - Ph.D. (Med.), Head of the Laboratory of Clinical and Experimental Biochemistry and Immunology Research Institute medekologii, Chita State Medical Academy. E-mail: tpp6915@mail.ru
M.V. Maksimenya - Ph.D. (Biol.), Research, Scientist Laboratory of Clinical and Experimental Biochemistry and Immunology Research Institute medekologii, Chita State Medical Academy. E-mail: mmv4510@mail.ru
E.E. Gergesova - Ph.D., (Med.), Government Institution of Public Health Territorial Children-s Consultive-diagnostic Centre, Laboratory Doctor. E-mail: kish1209@yandex.ru
O.K. Plotnikova - Assistant, Department of Chemistry and Biochemistry, Chita State Medical Academy. E-mail: pok8474@mail.ru
Abstract:
The spectra of long chain fatty acids (LCFA) and cytokines in a diseased skin in patients with psoriasis were studied. Imbalance in the spectrum of LCFA identified. It was characterized by a deficit of polyene acids on the background of increasing levels of saturated analogs, mainly with an odd number of carbon atoms, and monoene compounds. The shift of cytokine profile in the direction of proinflammatory (IL-1β, IL-8, TNF-α, IFN-α) and mytogene factors on the background of stable values of anti-inflammatory cytokine IL-4 revealed. We determined significant direct correlations between the level of IL-1β and numbers C20:5ω3.
Pages: 65-70
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