S.A. Lebedeva - Ph.D. (Biol.), Junior Research Sciences, JSC «All-Russian centre of science on safety of biologically active substances», Staraya Kupavna, Russia. E-mail: lebedeva502@yandex.ru
F.B. Litvin - Dr. Sc. (Biol.), Smolensk State Academy of Physical Culture, Sport and Tourism, Smolensk, Russia
A.Z. Shakhmardanov - Ph.D. (Biol.), Hiding Research Sciences, All-Russian scientific research Institute of physiology, biochemistry and nutrition of farm animals, Borovsk, Russia

The hypoxic condition, altering energy tissues lead to a hemodynamic disturbances in the microvasculature. That is why the study of the influence of substances with a strong antihypoxic effect on indicators of microcirculation and oxygen is such interesting. During experiments with 40 white nonlinear mice-males was studied the effect of 2 new metal complexes of cobalt (CoALL) and iron (Tetravim) on the basis of 1-alkeniimidazol with the expressed antihypoxic effect on microcirculation and tissue oxygenation. Method of laser Doppler flowmetry determined the state of the microcirculation on the outer surface of leather thigh rear limbs of the animal. Microcirculation index (PM), index perfusion oxygen saturation in microcirculation (Sm), saturation of arterial blood (SPO2), saturation mixed blood (M), the index of specific consumption of oxygen (U), the relative volume fraction of erythrocytes (VR) and the efficiency of oxygen exchange were estimated. Student-st-test was used for statistical processing of the material. Differences in the results were considered significant when p ≤ 0.05. It was established that the compounds in a dose of 50 mg/kg, i/p significantly influenced the microcirculation system of mice. The improved PM on 28-37 %, efficiency of oxygen exchange 1.4-2.4 times, VR on 46-59 % (p ≤ 0.05). With the introduction of CoALL significantly U increased 2.3 times and SPO2 on 23 % in comparison with the animals of the control groups. The above-mentioned changes in the system of microcirculation contribute to the improvement of hypoxic stability tissues and are of interest to the explanation of the mechanism antihypoxic actions studied metal complexes of cobalt and iron.