350 rub
Journal №1 for 2014 г.
Article in number:
Development of pharmaceutical dosage forms based on metal nanoparticles
Keywords: copper nanoparticles dosage forms laboratory production schedules methylcellulose derivatives identity stability quality assessment
Authors:
A.A. Rakhmetova - Ph.D. (Biol.), Associate Professor, Federal State Institution of Science Institute of Energy Problems of Chemical Physics, Russian Academy of Sciences V.L. Tal'roze Russia, Moscow. E-mail: alla8405@yandex.ru
O.A. Bogoslovskaya - Ph.D. (Biol.), Associate Professor, Federal State Institution of Science Institute of Energy Problems of Chemical Physics, Russian Academy of Sciences V.L. Tal'roze, Moscow. E-mail obogo@mail.ru
O.A. Semkina - Ph.D. (Рharm.), Associate Professor, Federal State Budgetory Educational Higher Professional Institution of Education «Peoples' Friendship University of Russia. E-mail: nanobiology@rambler.ru
M.N. Ovsyannikova - Ph.D. (Biol.), Federal State Institution of Science Institute of Biochemical Physics Russian Academy of Sciences N.M. Emanuel. E-mail: nanobiology@rambler.ru
I.P. Olkhovskaya - Senior Research Scientst, Federal State Institution of Science Institute of Energy Problems of Chemical Physics, Russian Academy of Sciences V.L. Tal'roze, Moscow. E-mail: nanobiology@rambler.ru
N.N. Gluschenko - D. Sc. (Biol.), Professor, Chief of Laboratory, Federal State Institution of Science Institute of Energy Problems of Chemical Physics, Russian Academy of Sciences V.L. Tal'roze, Moscow. E-mail: nnglu@mail.ru
Abstract:
The research presented in the article, focuses on the development of technology for pharmaceutical dosage forms with metal nanoparticles. As an active substance copper nanoparticles with desired physical and chemical characteristics and demonstrating high biological activity were used. We focused our efforts at the development of composition and laboratory regulations for production of ointments with copper nanoparticles (NPs) based on derivatives of methylcellulose: a water-soluble methyl cellulose (MC-100), hydroxypropyl methylcellulose (HPMC), sodium carboxymethyl cellulose (Na-CMC). Quality control of ointments with copper nanoparticles was performed for parameters: «Appearance», «uniform», «Colloidal stability», «Water content and volatile», «pH» and «viscosity». Samples of obtained ointments were white, homogeneous in composition, without mechanical impurities, with a weak characteristic odor. The pH of ointments was in the range of 5.0 to 6.8, which is close to the physiological pH of the skin. Mean mass fraction of water and volatile matter was 75.5 %. Ointments were resistant to separation by centrifugation upto 7000 rev/min. Ointments with copper nanoparticles on the basis of MC-100 and HPMC were found to have the best consistency. An evaluation of the quality and stability proves that ointments, prepared by this process flow, meet the requirements of ND limits for pharmaceutical dosage forms. To determine the authenticity of pharmaceutical dosage forms with metal nanoparticles a scanning electron microscopy was used.
Pages: 27-32
References
  1. Wright J.B., Lam K., Buret A.G. et al. Early healing events in a porcine model of contaminated wounds: effects of nanocrystalline silver on matrix metalloproteinases, cell apoptosis, and healing // Wound Repair Regen. 2002. V. 10(3). P. 141-151.
  2. Patent 2296571 (RF). Ranozazhivlyayushhij sostav i sposob ego polucheniya / T.A. Bajtukalov, N.N. Glushhenko, O.A. Bogoslovskaya, I.P Ol'xovskaya, G.E'. Folmanis, I.P. Arsent'eva.
  3. Patent 2460532 (RF). Preparat, uskoryayushhij ranozazhivlenie / O.A. Bogoslovskaya, A.A., Raxmetova, N.N. Glushhenko, M.N. Ovsyannikova, I.P. Ol'xovskaya, V.P. Varlamov, A.N. Levov, A.V. Il'ina, A.A. Zubareva.
  4. Raxmetova A.A., Alekseeva T.P., Bogoslovskaya O.A., i dr. Ranozazhivlyayushhie svojstva nanochasticz medi v zavisimosti ot ix fiziko-ximicheskix xarakteristik // Rossijskie nanotexnologii. 2010. T. 5. № 3-4. S. 62-67.
  5. Gen M.Ja., Miller A.V. Avtorskoe svidetel'stvo SSSR № 814432 // Byulleten' izobretenij. 1981. N 11. S. 25.
  6. Gosudarstvennaya farmakopeya Rossijskoj Federaczii, XII izd. Ch.1. Moskva. 2007.
  7. GOST 7142-74. Smazki plastichny'e. Metody' opredeleniya kolloidnoj stabil'nosti. 1975.
  8. Gosudarstvennaya farmakopeya SSSR, XI izd. Obshhie metody' analiza. Vy'p. 1,2. M.: Mediczina. 1989.
  9. GOST 52343-2005. Kremy' kosmeticheskie. Obshhie texnicheskie usloviya. 2005.
  10. Polimery' v farmaczii / pod red. A.N. Tenczovoj, M.T. Alyushina. M.: Mediczina. 1985.
  11. Perczev I.M., Daczenko B.M., Gun'ko V.G. Mnogokomponentny'e mazi na gidrofil'noj osnove // Farmacziya. 1990. № 5. S. 73-77.
  12. Pankrusheva T.A. E'ksperimental'no-teoreticheskoe obosnovanie sozdanie myagkix LF na polimerny'x osnovax - proizvodny'x czellyulozy': diss. ... d-ra farm. nauk. Kursk. 1995.