350 rub
Journal №9 for 2013 г.
Article in number:
Inculin-like growth factors in breast cancer patients - serum
Keywords: IGF-1 IGF-2 breast cancer
Authors:
A.V. Maslyaev - Oncologist, Russian N.N. Blokhin Cancer Research Center RAMS (Moscow) O.I. Kostyleva - PH.D. (Med.), Senior Research Scientist, Clinical biochemistry laborator, Russian N.N. Blokhin Cancer Research Center RAMS (Moscow) E.S. Gershtein - Dr.Sc. (Biol.), Professor, Leading Research Scientist, Clinical biochemistry laborator, Russian N.N. Blokhin Cancer Research Center RAMS (Moscow). E-mail: esgershtein@gmail.com V.D. Ermilova - Ph.D. (Med.), Leading Research Scientist, Russian N.N. Blokhin Cancer Research Center RAMS (Moscow) I.V. Vysotskaya - Dr.Sc. (Med.), Professor, First Moscow State Medical University I.M. Sechenov V.M. Gritskevich - Applicant, Moscow State Medical and Dental University A.I.Evdokimova S.M. Portnoy - Dr.Sc. (Med.), Russian N.N. Blokhin Cancer Research Center RAMS (Moscow)
Abstract:
Insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) were measured by ELISA techniques in blood serum of 79 primary breast cancer patients and 16 control practically healthy women. Significant increase of IGF-1 level and decrease of IGF-2 level were demonstrated in patients - sera as compared to control group. Serum IGF-1 level was also higher in premenopausal patients than in those in menopause. Both markers were increased in patients with HER2/neu-negative tumors, and tumors with positive steroid receptor status. No associations were found between serum IGF-1 and IGF-2 levels and main criteria of breast cancer progression.
Pages: 68-71
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