350 rub
Journal №8 for 2013 г.
Article in number:
Inculin-like growth factors in colorectal cancer patients - serum
Keywords: IGF-1 IGF-2 IGFBP-1 IGFBP-3 colorectal cancer
Authors:
E.S. Gershtein, A.A. Nikolayev, E.A. Korotkova, N.E. Kushlinskii
Abstract:
Insulin-like growth factors (IGF) 1 and 2 and IGF binding proteins (IGFBP) 1 and 3 levels were measured by ELISA techniques in blood serum of 74 primary colorectal cancer patients and 30 control practically healthy persons. Significant increase of IGF-1 level and decrease of IGFBP-3 level were demonstrated in patients - sera as compared to control group. Sensitivity of IGF-1 as a prospective diagnostic colorectal cancer marker comprised 80 % with 75 % specificity using 140 ng/ml as cut-off level. Significant negative association was found between both patients and donors - age and serum IGF-1 levels, but in CRC patients it was much weaker than in control group. No associations were found between serum IGF 1 and 2 levels and main criteria of colorectal cancer progression.
Pages: 69-75
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