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Journal №5 for 2013 г.
Article in number:
Suppositories development based on dry extract leaved arnica
Keywords: Arnika foliosa dry extract the basis suppository technology of suppositories
Authors:
V.F. Okhotnikova, N.S. Miheeva, O.A. Semkina, M.A. Dzhavakhyan, A.F. Azarkova, T.V. Kachalina, T.A. Sokolskaya
Abstract:
With the purpose of a choice of optimum structure suppository the widely used bases were used: Supporin M, Firm fat of the mark A, Vitepsol W-35, Supacir NaS, PEG. On the basis of the carried out experimental data the conclusion is made that optimum suppository base on the basis «Firm fat» (Adepssolidus) .With the purpose of obtaining fine-dispersed and stable emulsions are used monohlycerides. As the solvent of medicinal substance is used 1,2 propylene glycol. As superficial - active substance strengthening intensity diffusion and absorption of substances in a straight rectum at the expense of increase of their solubility and influence on mucous by decrease of a superficial tension of a layer, the Twin-80 is included. The estimation of the quality of suppositories according to the GF XI.
Pages: 11-15
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