350 rub
Journal №4 for 2013 г.
Article in number:
Evaluation of tumor necrosis factor α and interleukin 6 content in parotid salivary fluid of ductal chronic sialadenitis patients
Keywords: saliva ductal sialadenitis TNF-α IL-6
Authors:
А.S. Aleinikov, I.V. Gaiduk, E.S. Gershtein, A.M. Panin, N.E. Kushlinskii
Abstract:
18 patients with exacerbation of chronic ductal sialadenitis underwent standard anti-inflammatory complex therapy, and after abatement of acute inflammation salivary fluid was collected. TNF-α and IL-6 content in parotid gland salivary fluid was measured by ELISA techniques. Highly significant concordant increase of TNF-α and IL-6 levels was found in saliva in subacute stage inflammatory phase as compared to remission. IL-6 level was significantly positively associated with disease stage and clinical character of inflammatory process.
Pages: 50-56
References
  1. Afanasev V.V. Sljunnye zhelezy bolezni i travmy // GEHOTAR-Media. 2012. S. 103 - 163.
  2. Romacheva I.F., JUdin L.A., Morozov A.N. Zabolevanija i povrezhdenija sljunnykh zhelez // Medicina. 1987. 240 s.
  3. Panin A.M., Gajjduk I.V.KHirurgicheskaja stomatologija - vospalitelnye i distroficheskie zabolevanija sljunnykh zhelez. M. Literatura. 2011. S. 126 - 143.
  4. Wang Y., Shnyra A., Africa C., Warholic C., McArthur C. Activation of the extrinsic apoptotic pathway by TNF-alpha in human salivary gland (HSG) cells in vitro, suggests a role for the TNF receptor (TNF-R) and intercellular adhesion molecule-1 (ICAM-1) in Sjogren\'s syndrome-associated autoimmune sialadenitis // Arch. Oral. Biol. 2009. V. 54. № 11. P. 986 - 996.
  5. Matsumura R., Umemiya K., Kagami M., Tomioka H., Tanabe E., Sugiyama T., Sueishi M., Kayagaki N., Yagita H., Okumura K. Expression of TNF-related apoptosis inducing ligand (TRAIL) on infiltrating cells and of TRAIL receptors on salivary glands in patients with Sjogren\'s syndrome // Clin. Exp. Rheumatol. 2002. V. 20. № 6. P. 791 - 798.
  6. Yamakawa M., Weinstein R., Tsuji T., McBride J., Wong D.T., Login G.R. Age-related alterations in IL-1beta, TNF-alpha, and IL-6 concentrations in parotid acinar cells from BALB/c and non-obese diabetic mice // J. Histochem. Cytochem. 2000. V. 48. № 8. P. 1033 - 1042.
  7. Tsuneyama K., Saito K., Ruebner B.H., Konishi I., Nakanuma Y., Gershwin M.E. Immunological similarities between primary sclerosing cholangitis and chronic sclerosing sialadenitis: report of the overlapping of these two autoimmune diseases // Dig. Dis. Sci. 2000. V. 45. P. 366 - 372.
  8. Baggiolini M., Clark-Lewis I. Interleukin-8, a chemotactic and inflammatory cytokine // FEBS Lett. 1992. V. 307. № 1. P. 97 - 101.
  9. Tanaka M., Miyajima A. Oncostatin M, a multifunctional cytokine // Rev. Physiol. Biochem. Pharmacol. 2003. V. 149. P. 39 - 52.
  10. Lee H.M., Cho J.G., Kang H.J., Chae S.W., Hwang S.J., Jung K.Y., Woo J.S. Expression of oncostatin M in chronic obstructive sialadenitis of the submandibular gland // Ann. Otol. Rhinol. Laryngol. 2008. V. 117. № 5. P. 347 - 352.
  11. Cauli A., Yanni G., Pitzalis C., Challacombe S., Panayi G.S. Cytokine and adhesion molecule expression in the minor salivary glands of patients with Sjögren\'s syndrome and chronic sialoadenitis // Ann. Rheum. Dis. 1995. V. 54. № 3. P. 209 - 215.
  12. David T. Wong. Salivary Diagnostics // Wiley-Blackwell. 2008. P. 167 - 174.