T.Y. Obergan, T.A. Shubina, M.E. Grigorieva, L.A. Lyapina, N.F. Myasoedov, L.A. Andreeva, V.E. Pastorova

Influence of peptide Pro-Gly-Pro-Leu on hemostatic and insular organism systems at the experimental diabetes of type II is investigated. It is established that intranasal introduction Pro-Gly-Pro-Leu (1 mg/kg of weight of a body, 1 time a day within 4 days) to rats with a proof hyperglycemia led to increase anticoagulant and fibrinolytic plasma potential of animals blood and to decrease in level of sugar in blood. Strengthening fibrinolytic properties of plasma occurred as at the expense of increase total and non-enzymatic fibrinilysis, and increases of tissue plasminogen activator activity. In these conditions the peptide didn\'t show antiplatelet activity. In the further experiments 5-fold intranasal introduction of Pro-Gly-Pro-Leu to rats in a dose of 1 mg/kg of weight of a body 2 times a day against development of a proof hyperglycemia led to normalization of the broken functions anticoagulant and insular systems of organism. So the investigated peptide rendered not only hypoglycemic action and raised anticoagulant and fibrinolytic plasma potential of animal blood, but also led to decrease of platelet aggregation. Thus indicators of a hemostasis and sugar level were restored to values which are characteristic for healthy animals. Restoration of hemostasis and regation and normalization of sugar level which is characteristic for healthy animals. Proof hypoglycemic effect and increase of anticoagulant blood potential remained throughout five days after cancellation of introduction of the peptide.