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Journal №4 for 2013 г.
Article in number:
Stady of Hypoglycemic activity of oxovanadium complexes on the basis of hetarylamides of 4-aryl-2-hydroxy-4-oxo-2-butenoic acid
Keywords: complex compounds of vanadium (IV) hypoglycemic activity
Authors:
N.A. Pulina, A.I. Krasnova, T.A. Yushkova, V.V. Yushkov, F.V. Sobin
Abstract:
The reaction of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids with vanadyl sulfate gives corresponding bis{3-aryl-1-[2(3)-pyridyl] carboxamido-1,3-propandionato}oxovanadium and bis{3-aryl-1-[2(5-R-1,3,4-thiadiazolyl)]carboxamido-1,3-propandionato}oxovanadium is studied. Hypoglycemic activity and acute toxicity of complex compounds together with starting ligands are described. The obtained metal complexes are found to belong to danger class 4 and less toxic than metformin. It is revealed that hypoglycemic activity is mostly affected by introduction of 2(3)-pyridyl fragment into oxovanadium complex structure.
Pages: 26-30
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