E.A. Vasilenko

Grass ground ivy extract was prepared in accordance with the requirements of pharmacopeiaXI editions, using as an extract ethyl alcohol 40 %. The received spirit extraction in acute experiment according to M.D. Litvinchuk and Z.I. Novosilets (1980) at single introduction caused the increased allocation in healthy white rats (for 52,9 %; p < 0,05) bile without essential changes in the ratio in bile of amount of cholesterol and bilious acids. In chronic experiments on white rats with hepatosis, induced by carbon tetrachloride, two-week oral administration of alcoholic extract of grass ground ivy at a dose of 92 mg/kg (corresponding to 1/30 LD50 and pharmacological screening of hepatotoxicity extraction according to V.V. Gatsura [1974]) situation explained statistically significant normalizing effect on the level of blood biochemical parameters characterizing the functional state of the hepar: albumin, creatinine, urea, cholesterol, triglycerides, total bilirubin, alkaline phosphatase, cholinesterase, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, which are determined by automatic biochemical analyzer BS-120 («Minzey», China) with a standard set of reagents («Diasis», Germany).The results of experiments allow to conclude that spirit extraction from a herb of ground ivy possess distinct hepatoprotective activity and herb ground ivy can serve as perspective vegetable raw materials for receiving remedies.