350 rub
Journal №3 for 2013 г.
Article in number:
Analysis of functional structural fragments for substances with 5-НТ2- and 5-НТ3-antagonistic activities
Keywords: receptors serotonin benzimidazoles
Authors:
M.V. Chernikov, P.M. Vasiliev, A.A. Spasov
Abstract:
According to the goal of this study pharmacophore analysis of new bi- and tricyclic benzimidazole derivatives and common agents with 5-НТ2- and 5-НТ3-antagonist activities was performed. For in silico analysis, computing technology of chemical compounds - biological activity prediction «Microcosm» was used. As a result of this work, some structural similarities and peculiarities of benzimidazole derivatives such as tertiary amino group for compounds with 5-НТ2- and 5-НТ3-activities and/or imino group including position within the pentamerous heteroaromatic cycle - for substances with 5-НТ2-activity were described.
Pages: 38-41
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