350 rub
Journal №12 for 2013 г.
Article in number:
The functional state of erythrocyte membranes and liver in experimental diabetes mellitus and duodenal ulcer in rats
Keywords: streptozototsinovy diabetes insulin receptors lipid peroxidation oxidative stress membrane-bound enzymes
Authors:
A.E. Gurina - Ph.D. (Med.), Department of Biological Chemistry, Faculty of Medicine, Russian National Research Medical University them. Pirogov, Moscow
N.P. Mikaelyan - Dr.Sc. (Biol.), Professor, Department of Biological Chemistry, Faculty of Therapeutics, Russian National Research Medical University them. Pirogov, Moscow. E-mail: ninmik@yandex.ru
A.A. Terentev - Corresponding Member, RAMS, Professor, Head of Department of Biological Chemistry, Russian National Research Medical University them. Pirogov, Moscow
I.O. Kulaeva - Post-graduate Student, Medical Faculty, Russian National Research Medical University them. Pirogov, Moscow
S.D. Mikhailova - Dr.Sc. (Med.), Professor, Head of Laboratory RL Pathology of the Cardiovascular System, Russian National Research Medical University them. Pirogov, Moscow. E-mail: labcvs@rsmu.ru
Abstract:
170 rats «Wistar» in experimental diabetes mellitus associated with a duodenal ulcer, and studied the functional activity of erythrocyte membranes and hepatocytes. These results suggest that lipid disorders associated with activation of processes lipid peroxidation, which is manifested as an increase in the content of primary and secondary products of lipid peroxidation, alteration of the functional properties of membranes, as well as disturbances in the antioxidant defense system. Against the background of insulin deficiency in EDS increased lipid peroxidation in erythrocyte membranes and in liver homogenates leads to disruption of lipid-protein relationships and reduce the activity of insulin receptors and enzymes, SOD, catalase, CCO and LDH. Violation insulinreceptors interaction leads to a decrease in glucose uptake in the studied tissues by lowering the activity of insulin receptors, especially pronounced ulcer duodenum against streptozotocin diabetes.
Pages: 37-41
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