N.A. Polyakov - Ph.D., Leading Research, All-Russian Scientific Research Institution for Medicinal and Aromatic Plants (VILAR), Moscow, Russia. Е-mail: polakov@yandex.ru
V.A. Dubinskaya - Ph.D., Leading Research, All-Russian Scientific Institute of Medicinal and Aromatic Plants (VILAR), Moscow, Russia. E-mail: va@diamsoft.ru
D.S. Kachalin - Post-graduate Student of Department of Pharmaceutical Technologies of All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (VILAR), Russia
V.F. Okhotnikova - Ph.D.(Pharm.), Manager of Pharmaceutical Technology Section, All-Russian Scientific Institute of Medicinal and Aromatic Plants (VILAR), Moscow, Russia. E-mail: vilarnii@mail.ru
T.V. Kachalina - Ph.D.(Pharm.), Leading Research Worker, All-Russian Institute of Medicinal and Aromatic Plants, Moscow, Russia. E-mail: t.kachalina@rambler.ru
T.А. Sokolskaya - Dr.Sc.(Pharm.), Professor, Russian Science Research Institution for Medicinal and Aromatic Plants (VILAR). E-mail: vilarnii@mail.ru

The development of effective, safe pharmaceutical drugs with appropriate level of quality is important. The solution to this problem is to use science-based approach of studying properties and technological characteristics of dosage forms and their components by modern methods. Already at early stage of development of dosage forms possible interactions of components should be identified to predict incompatibility of individual components, to identify compositions of tablet and temperature conditions during manufacture and storage. Developed scientific based assessment of physico-chemical properties of components of solid dosage forms by modern methods allows to predict the compatibility of excipients and active ingredient, to study the nature of their interaction, to conduct selection of excipients, as well as to determine the presence of drug substance lutenurinum in the solid dosage form.