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Journal №11 for 2013 г.
Article in number:
Preclinical study of safety antimicrobial рhytodrug Sanguiritrin
Authors:
L.V. Кrepkova - Ph.D. (Biol.), Head of Toxicology Department, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (VILAR), Moscow, Russia V.V. Bortnikova - Ph.D. (Biol.), Head of the Laboratory Drug Toxicology, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (VILAR), Moscow, Russia
Abstract:
Preclinical study of antibacterial phytodrug sanguiritrin, isolated from the grass of Macleaya cordata (Willd.) R. Br.) and Macleaya microcarpa (Maxim.) Fedde (Papaveraceae) have been studied. Sanguiritrin, is a mixture of bisulfats two alkaloids sangvinarina and heleritrina. On the parameters of toxicity by a single intraperitoneal and intragastric introduction mice, rats and cavies sanguiritrin belongs to a class of moderately toxic substances. In chronic 90-day experiment on rats case of introduction into stomach sanguiritrin in a dose of 2 mg/kg had expressed toxic effect on hematological, biochemical, functional, pathohistological indicators. Sanguiritrin doses of 10 and 50 mg/kg (1/50 and 1/10 of LD50) in the application of per` os can have toxic effects on hepatobiliary and the excretory system of rats. Repeated applications sanguiritrin liniment 0.5 % on back skin of rabbits does not cause a damaging effect on the internal organs and systems of the organism, do not irritate the skin at the site of the preparation. Sanguiritrin has a pronounced local irritant action. The sanguiritrin not identified embryotoxic, teratogenic, allergenic, mutagenic and carcinogenic properties. Phytodrug sanguiritrin as a liniment of 0.5 % is permitted for use in surgical, gynaecological, dental and оtolaryngology practice, the results of which confirmed its low toxicity and good tolerability.
Pages: 57-63
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