350 rub
Journal №8 for 2012 г.
Article in number:
Gas Chromatography Coupled with Mass Spectrometric Detection as a New Method for Determination of Major Metabolites of Adrenaline, Noradrenaline, Dopamine and Serotonin of Patients with Drug Addiction
I.S. Mamedov, P.B. Glagovsky, Y.A. Smolina, V.V. Yurasov, R.T. Toguzov
The relationship of drug use and various metabolic disorders has been studied for a long time in Addiction. It is known that virtually all drugs in their application alter the activity of the sympathoadrenal system, the main biologically active substances which are norepinephrine, epinephrine and dopamine, called catecholamines. The article studies influence of drug use on the metabolism of catecholamines and serotonin, and searching of new algorithms for diagnosis of various drug addictions. The article highlights the processes of synthesis and regulation of the release of catecholamines and serotonin in the body, mechanisms of action and metabolism of the compounds. The possibility of using the major metabolites of catecholamines and serotonin: homovanillic, vanilinmindalic and 5-hydroxyindoleacetic acid as biochemical markers for the diagnosis of drug dependence. The dynamics of changes in the concentrations of metabolites of adrenaline, noradrenaline and serotonin, depending on the size of the dose consumed by the example of heroin and amphetamines. A comparative study of the chromatographic methods of analysis of these compounds.
Pages: 65-72
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