350 rub
Journal №8 for 2012 г.
Article in number:
Gas Chromatography Coupled with Mass Spectrometric Detection as a New Method for Determination of Major Metabolites of Adrenaline, Noradrenaline, Dopamine and Serotonin of Patients with Drug Addiction
Keywords: narcotism catecholamines serotonin diagnostics
Authors:
I.S. Mamedov, P.B. Glagovsky, Y.A. Smolina, V.V. Yurasov, R.T. Toguzov
Abstract:
The relationship of drug use and various metabolic disorders has been studied for a long time in Addiction. It is known that virtually all drugs in their application alter the activity of the sympathoadrenal system, the main biologically active substances which are norepinephrine, epinephrine and dopamine, called catecholamines. The article studies influence of drug use on the metabolism of catecholamines and serotonin, and searching of new algorithms for diagnosis of various drug addictions. The article highlights the processes of synthesis and regulation of the release of catecholamines and serotonin in the body, mechanisms of action and metabolism of the compounds. The possibility of using the major metabolites of catecholamines and serotonin: homovanillic, vanilinmindalic and 5-hydroxyindoleacetic acid as biochemical markers for the diagnosis of drug dependence. The dynamics of changes in the concentrations of metabolites of adrenaline, noradrenaline and serotonin, depending on the size of the dose consumed by the example of heroin and amphetamines. A comparative study of the chromatographic methods of analysis of these compounds.
Pages: 65-72
References
  1. Shoptaw S.J., Kao U., Heinzerling K., Ling W. Treatment for amphetamine withdrawal // Cochrane Database Syst. Rev. 2009. Apr 15. (2). CD003021.
  2. Nelson D.L. 5-HT5 receptors // Current drug targets. CNS and neurological disorders. 2004. V. 3 (1). P. 53-8
  3. Kwang S.R., Jong S.Y. The simultaneous determination of HVA, VMA and 5-HIAA by GC/MS // Seoul Clinical Laboratory. 1996. V. 1. P. 121-125.
  4. Carl-Gunnar Swahn1, Bengt Sandgärde1, Frits-Axel Wiesel1,Göran Sedvall. Simultaneous determination of the three major monoamine metabolites in brain tissue and body fluids by a mass fragmentographic method // Psychopharmacology. 1976. V. 48. № 2. January.
  5. Glroni A., Seghieri G., Niccolai M., Mammini P.Simultaneous Liquid-Chromatographic Determination of  Urinary Vanillylmandelic Acid, Homovanillic Acid, and 5-Hydroxyindoleacetic Acid // Clin. Chem. 1988. V.34 (12). P. 2504-2506.
  6. Schildkraut J.J., Meyer R.E., Orsulak P.J., Mirin S.M., Roffman M., Platz P.A., Grab E., Randall M.E., McDougle M. The effects of heroin on catecholamine metabolism in man // Natl. Inst. Drug. AbuseRes. Monogr. Ser. 1975. V. 3. № 137-145.
  7. Иванец Н.Н., Анохина И.П., Винникова М.А. // Сб. Опыт применения антаксона при лечении опийной наркомании. М. 2000. 29 с.
  8. Анохина И.П., Иванец Н.Н. Веретинская А.Г., Винникова М.А. Влияние антаксона на клинические симптомы и нейрохимические процессы при героиновой наркомании // Вопросы наркологии: Научно-практический журнал. 2004. № 3. С. 3-9.
  9. Физиология человека (Compendium) 2-е изд. испр. и перераб. / под ред. акад. РАМН Б.И. Ткаченко и проф. В.Ф. Пятина. Самарскийдомпечати. 2002. 416 с.
  10. Milanés M.V., Fuente T., Laorden M.L.Catecholaminergic activity and 3',5'-cyclic adenosine monophosphate levels in heart right ventricle after naloxone induced withdrawal // Naunyn. Schmiedebergs Arch. Pharmacol. 2000 Jan. V. 361(1). P. 61-66.
  11. Capela J.P., Macedo C., Branco P.S., Ferreira L.M., Lobo A.M., Fernandes E., Remião F., Bastos M.L., Dirnagl U., Meisel A., Carvalho F.Neurotoxicity mechanisms of thioether ecstasy metabolites // Neuroscience. 2007. Jun 8. V. 146(4). P. 1743-1757.
  12. Kankaanpää A., Meririnne E., Lillsunde P., Seppälä T. The acute effects of amphetamine derivatives on extracellular serotonin and dopamine levels in rat nucleus accumbens // Pharmacol. Biochem. Behav. 1998. Apr. 59(4). P. 1003-1009.