350 rub
Journal №5 for 2012 г.
Article in number:
Biochemical investigation of left ventricular myocardial cell apoptosis in experimental arterial hypertension
Keywords: apoptosis caspase myocardium arterial hypertension
Authors:
M.M. Azova, M.L. Blagonravov, V.A. Frolov
Abstract:
Arterial hypertension (AH) is one of the dominant cardiovascular disorders that can often result in heart failure. It has been suggested that apoptosis may play a key role in heart failure as it causes the progressive loss of cardiomyocytes. Despite of many experimental data in this area, regulators of death and survival pathways in myocardial cell response to AH require further study. The experiment was performed on adult male Chinchilla rabbits in which arterial hypertension was modeled by abdominal aorta banding by 1/3 of its initial diameter. 1, 2 and 4 weeks later caspase-3 activity was measured in left ventricular myocardial cells. The activity significantly increased 4 weeks after modeling of AH. These results demonstrated enhanced apoptosis in left ventricular myocardial cells in experimental arterial hypertension. Caspase-8 activity was determined at 4 weeks after surgery. Absence of significant increasing of the activity indicated the predominance of intrinsic apoptogenic signals.
Pages: 27-31
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