M.V. Gavrilin, S.P. Senchenko, M.V. Larsky

The main aim of this investigation was a comparative study of pharmacokinetic parameters of the two antihypertensive drugs containing lisinopril dihydrate. We used tablets lisinopril 10 mg (JSC «Organics») and diroton (JSC «Gedeon Richter Pharmaceutical Plants»). The study of concentration profiles of unchanged active substance was performed using serum of rats after a single-dose oral administration of suspension powder triturated tablets at a dose of 100 mg/kg (based on lisinopril). Determination of lisinopril was performed by capillary electrophoresis in 10 mg/ml borate buffer solution (pH 9,18) at 20 °C, voltage 20 kV, peak detection was performed by spectrophotometry at 190 nm, the separation time - 15 minutes. The results allowed to construct a standard concentration curve of lisinopril. For their description two-chamber model with absorbtion was used; the main pharmacokinetic parameters were calculated. It was investigated that the level of biological availability of Lisinopril tablets is 28 % higher than for the prototype. At the same time Lizinopril tablets are slower release in blood. So it provides more gradual therapeutic effect. At the same time, the domestic drug slowly absorbed into the blood, which provides a gradual onset of therapeutic effect. Because of bioavailability differences aren-t so significant (according to Сmax/AUC∞), it is possible to consider these medicinal forms as bioequivalent.